ABSTRACT
OBJECTIVE: To observe the results of chondrodiastasis / physeal distraction in the management of pseudarthrosis of tibia by Ilizarov ring fixator
PATIENTS AND METHODS: Nine patients, seven males and two females, with congenital pseudarthrosis of tibia were treated from February2008 to April 2012. The age at the onset of Ilizarov treatment was 10 to 12 years. Meticulous and complete resection of the sclerotic bone ends and surrounding fibrous hamartoma, and reopening of the medullary canals was done. Two navigation wires were passed through both the malleoli. Generous autogenous bone graft was placed, harvested from the ipsilateral iliac crest. Advanced hybrid Ilizarov ring fixator was applied. Acute compression at the pseudarthrosis site was done. One ring was applied in the proximal tibial epiphysis. Fracture was done at proximal physeal plate by rotatory movements. Fibula attached proximally and distally to proximal and distal rings. Distraction was started on the 5th day at the rate of 0.5 mm/24 hours for 10 days. Later on distraction rate was accelerated to 1mm/day with a rhythm of 0.25 mm/6 hourly. Ankle deformities were addressed accordingly
RESULTS: Union was achieved in all the nine cases at the time of frame removal. All the other associated deformities were addressed simultaneously while the frame was on. Leg length discrepancy was addressed by physeal distraction. Growth was not arrested in all cases after physeal distraction
CONCLUSION: Ilizarov ring fixator remains the treatment of choice to achieve refracture free union till 4 years in congenital pseudarthrosis of tibia, one of the most perplexing and challenging orthopedic problems. And there is no physeal arrest after physeal distraction to treat leg length discrepancy
ABSTRACT
Object: to assess the role of Topiramate in reducing migraine related disability and improvement in quality of life in migraine sufferers comparing with conventionally used drug propranolol
Background: Epilepsy and migraine have some biological features in common; therefore antiepileptic drugs are supposed to be effective in migraine prophylaxis beside active treatment, in reducing migraine headache attacks and therefore can improve sufferers' quality of life
Methods: seventy diagnosed patients of migraine were enrolled in the study and 64 completed the whole study period [12 weeks]. They were divided in two groups: A [Topiramate] and B [Propanolol]. MIDAS scores were observed at day-0 and day-90 and results were statistically Analyzed
Results: group received Topiramate showed better response and overall reduction was 62.51% [P-value<0.001] while in Propranolol group the reduction was 52.64% [p-value <0.001]
Conclusion: topiramate is superior than olden propranolol in reducing the migraine related disability and improving the daily activities related to job, school, household, family and social life. However propranolol is still effective in migraine prophylaxis