[Comparing the healing effects of topical phenytoin, conjugated estrogen and silver sulfadiazine on skin wounds in male rats]

Accelerating of skin wounds healing process has been focused by researchers in recent years. The aim of the present study was to compare the effects of topical phenytoin, silver sulfadiazine and conjugated estrogen on skin wounds healing in male rats. Accessing a way to accelerate skin wounds healing is still one of the important goals in medical science. This experimental study was accomplished on 32 male rats [8 animals in each group] with approximately equal body mass. Skin wounds were made with an area of 40 mm[2] and a depth of 0.5 mm on the back of the necks. Three groups were administered daily by topical phenytoin [1%], silver sulfadiazine [1%] and conjugated estrogen [625%]. Control group received no drug. Wounds healing was evaluated daily and the study was continued until the wounds healing completed. Silver sulfadiazine demonstrated to be the best treatment for the wounds healing; compared with the other medicines, it required significant shorter time of treatment. Silver sulfadiazine accelerates skin wounds healing in male rats

[Pyoderma gangrenosum in a patient with autoimmune haemolytic anemia]

Pyoderma gangrenosum [PG] is an uncommon, non-infectous, neutrophilic, ulcerative disease with typically starts with pustules which rapidly evolve to painful ulcers with undermined violaceous borders. The diagnosis of PG is based on clinical features and requires exculusion of other conditions that produce ulcerations. PG is associated with a variety of systemic diseases that the most commonly of them is include inflammatory bowel diseases, leukaemia, myeloma, monoclonal gammopathies, chronic active hepatitis, systemic lupus erythmatous and arthritis. Two cases of PG with haemolytic anemia have been reported and this patient is third one. Patient was a 19-year-old girls, with haemolytic anemia from 15 years ago. Who was referred with an ulcer, 2x3 cm in diameter, on her lower right leg with violaceous border and on her lower left leg with painful haemorrhagic bulla 4x6 cm in diameter. Because, PG in many cases is associated with an underlying disease in these patients, search for finding possible underlying diseases is necessary