ABSTRACT
Despite high prevalence rate of nausea vomiting and mead for treatment in severe cases which leads to electrolyte imbalances and weight loss, due to lack of knowledge about its cause, an elear-cut treatment for it, is still unavailable. In this study we compared the effect of prednisolone to that of pyridoxine on the treatment of severe cases of vomiting during the first half of pregnancy. In a double blind clinical trial study [2002-2003] 120 women with a normal intra uterine pregnancy and less than 22 weeks of gestational age with hyper emesis gravidarum were admitted to Zahedan Qhods hospital for appropriate treatment. Patients randomly divided in two groups of 60; patients, received prednisolone 5 mg/ TDS [case group] and the other 60 patients, received pyridoxine / 20mg/ TDS [control group]. 3 days later, serum electrolytes, severity of vomiting , beginning of diet, and response to treatment were studied. All patients were followed every week, up to 22 weeks of gestational age. There was no significant difference between the two groups with respect to maternal age, gestational age, and gravidity, and weight loss, number of previous admissions recent pregnancy. There was significant difference between the two groups in electrolyte disorders, start of feeding after 1-2 days from initiated treatment, recurrent admission 2 weeks after discharge and response to treatment [P