ABSTRACT
Leishmaniasis is a common cutaneous disease which is due to the infection with protozoan parasite named leishmania. This parasite is transmitted to a human by an infected sand fly. Both clinical forms of cutaneous leishmaniasis [dry-wet] are endemic in Khorasan province. The purpose of this study was to report two leishmaniasis cases with just lip involvement. This report is about two patients with lip leishmaniasis, without any skin or mucusal involvement in which the clinical features were diffuse lip swelling and ulcer in lower lip vermelion. These patients had been referred to oral medicine department of Mashhad dental school where a smear and biopsy were obtained which confirmed the clinical diagnosis of leishmaniasis. Thereafter, the patients were referred to a dermatologist for treatment. In later follow up, complete healing of lesions was observed. The city of Mashhad is one of the centers with high frequency of dry cutaneous leishmaniasis and facial involvement in this disease is common. So it is necessary for dentists to consider leishmaniasis in differential diagnosis of lip and nose swellings and ulcers