ABSTRACT
Background:Early detection of acute kidney injury (AKI) in burn-injured patients can help modify the treatment to prevent progression of acute renal failure and reduce the need for renal replacement therapy. The aim of the study was to evaluateurinary interleukin-18 in the early post-burn period to predict the AKIfor the various degrees of burn patients. Methods:This prospective observational study was conducted in the department of nephrology, Dhaka medical college in collaboration with burn and plastic surgery unit of the same medical college hospital, from July 2017 to June 2018 for a period of one year. The 48 burn patients (Age>18 years) who attended in the burn unit of Dhaka medical college, Dhaka of both sexes were enrolled in this study. Data were analyzedby using SPSS 22.0. A value of p<0.05 was considered statistically significant for all tests. Results:In this study, mean age of the burn patients was 32.41�.59 years. Male female ratio was 3.36:1. Urinary IL-18 in diagnosis of AKI showed accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 93.8%, 91.7%, 94.4%, 84.6% and 97.1% respectively. AUC for urinary IL-18 at admission was 0.968 (CI, 0.921-1.000) and AUC for serum creatinine at admission was0.937 (CI, 0.871-1.000).Conclusions:According to Kappa value, AUC and sensitivity and specificity urinary IL-18 is a good biomarker in predicting of early AKI in burn patients
ABSTRACT
To evaluate the efficacy of trimethoprim- sulfamethoxazole and oral prednisolone in the treatment of ocular toxoplasmosis with zone-1 posterior pole and peri-papillary lesions. Retrospective evaluation of records of patients in our tertiary care referral hospitals. 22 eyes of 21 patients with active toxoplasma retino-choroiditis in zone -1 posterior pole and peri-papillary areas were included in the study. One patient developed active lesion in the fellow eye after 6 months which regressed after re-institution of the treatment. There were 11 females and 10 males. Age varied between 18-52 [mean age 29 +/- 8.8] years. The follow-up period varied between 4-46 [mean 15 +/- 11] months. All patients showed resolution of retino-choroiditis and improvement of visual acuity between 1- 9 lines [mean 4.18 lines +/- 2.3].The mean lesion size pre-treatment was 0.89 disc diameters +/- 0.3 and post-treatment was 0.70 disc diameters +/- 0.28. The mean time taken for the sharpening of lesion borders was 2.3 +/- 0.4 [range 2-3] weeks. No complications reported with the medication. The combination of trimethoprim-sulfamethoxazole and prednisolone is quite effective in treating the patients with active vision threatening posterior pole and peri-papillary toxoplasmosis lesions