ABSTRACT
One of the mechanisms in reducing blood glucose is preventing the digestive absorbtion of glucose. The aim of this study was to investigate the viscosity and impact some plants useful in reducing the glucose and their effects on decreased glucose movmentvia via dialysis bag in vitro. Eleven traditional antihyperglycemic plants Liquid extracts were prepared after confirmation. The viscosity of the plant extracts was measured using viscometer. Different concentration [6.25, 12.5, 25, 50 g/l] of the extracts were addad to dialysis bag content D - glucose 0.22 M. Dialysis bag having only D - glucose 0.22 M was considered as control. The Liquid glucose concentration out of dialysis bag in room temperature was measured in time interval during 24 hours using the glucose oxidase method. The area under the glucose curve [AUC] was calculated using trapezium rule and AUC of different groups were compared. Highest viscosity was belonging to Pyrus biosseriana 50 g/l [1.69 mpas] and Securigera securidaca [1.46 mpas]. Decreased glucose movement from dialysis bag considering AUC was related to extracts of 50 g/l of Eucalyptus globulues [% 82]. Decreased glucose movment were extract concentration dependent but in the each extract concentration decreased glucose movement was less than control. The extracts of the traditional antihyperglycemic plants reduce the glucose diffusion in laboratory model. It seem that viscosity is effective in the decrease glucose movment, but this was not observed in case of Eucalyptus globulues extract, that probably another reason has a role in this relation
Subject(s)
Viscosity , Medicine, Traditional , Blood Glucose , Plants, Medicinal , Plant Extracts , Pyrus , Securidaca , EucalyptusABSTRACT
Chemotherapeutic agents are adjunctive substances for treatment of periodontitis through modulation of host response. Sodium alendronate is one of the medicaments which are used for this purpose. Since alkaline phosphates [ALP] level is an indicator for evaluation of bone metabolism changes, in this study the effect of sodium alendronate on periodontitis is investigated by measuring gingival crevicular fluid alkaline phosphates [GCF ALP] levels. In this double-blind experimental study, 24 patients [12 males and 12 females between the agen of 35 to 50 years] with moderate chronic periodontitis have been evaluated. All patients received scaling and root planning. Sodium alendronate and placebo capsules were used weekly in a period of six months for case and control groups respectively samples were collected in first visit, 3 months, and 6 month later and analyzed with spectrophotometry. Periodontal assessments were probing pocket depth, gingival index [loe and silness] and plaque index [silness and loe]. Data were analyzed by t-test, repeated measurement paired t-test. Mean changes of GCF ALP optical absorbtion were significant in case group through the period of 6 months, and in control group through the period of 3 months, however after 6 months in control group there is no significant changes in comparison with base line evaluations. During the study GCF ALP changes between two group were not significant statically. Mean changes of plaque index and gingival index were statically significant in both groups through 6 months period. Plaque index variations were significantly different between two groups. But duration of gingival index changes between 2 groups was insignificant. The use of sodium alendronate for 6 months improves periodontal parameters and decrease GCF ALP level, but these results are not so significant during this period of time