ABSTRACT
Background and Purpose: Patients whit body dysmorphic disorders have dysfunctional negative thoughts about their physical appearance. The purpose of this study was to evaluate the effectiveness of metacognitive intervention on body dysmorphic disorder in a 20-year-old male case
Methods and Materials: This case study used the single case experimental design to reduce the symptoms of a male patient with BDD diagnosis. To collect the data, the client completed the questionnaire in pre-test [as a base-line], last treatment session [as the post-test], and six months after treatment [follow-up]: Yale-Brown Obsessive Compulsive Scale Modified for BDD [YBOCS-BDD], Thought Fusion Instrument [TFI], Body Dysmorphic Metacognition Questionnaire [BDMCQ], and Beck Anxiety inventory [BAI]. For data analysis, the data chart analysis and graphical methods were used and based on the ascending and descending trend of the scores, effectiveness of the intervention was judged
Results: The scores for the pre-test, post-test, and follow-up examinations were 30, 10, and 10, respectively. His scores of the TFI were 820, 100, and 120, respectively. Finally, the scores for BDMCQ came up to be 45, 10, and 11, respectively, and the scores for [BAI] were: 47-16-18 respectively. Based on the clinical significance measures, the reduction of the symptoms was significant
Conclusion: The metacognitive intervention is effective in reducing the symptoms of the body dysmorphic disorder
ABSTRACT
Background and Purpose: P53 gene is a tumor suppressive gene and its product, P53 protein, is a protective factor against tumor formation that inhibits the extension of genetically damaged cells. P53 aggregation in tumoral cell nucleus is related with p53 gene mutations, which can be detected by immunohistochemical methods. This study was designed to investigate the protein aggregation in patients with gastric cancer in Gorgan, Iran
Methods and materials: All paraffin-embedded blocks of gastric cancer cases during the years 2000 to 2004 in the pathology ward of the 5th Azar Hospital in Gorgan, Iran [111 cases altogether] were evaluated and stained, for detecting microtome cutting. The obtained data were entered into SPSS and chisquare was used for analysis
Results: 111 cases with gastric cancer were investigated. The most frequent type of gastric tumor was adenocarcinoma [66.7%]. In 59.5% of the affected cases, P53 protein was detected. No significant relationship was observed between P53 expression and factors such as age, gender, and histological type of the tumor
Conclusions: In this study, P53 protein rate was high but it showed no significant relationship with other variables. We suggest further studies to discover the relationship between protein aggregation in tumor cells and other variables in affected cases