ABSTRACT
Chronic mental disorders are among the problems in psychiatrics. Atypical anti psychotic drugs are new effective medications to treat these disorders. Unfortunately these drugs lead to side effects such as increase in blood glocuse, weight gain and edema. This study aims to investigate adverse effects of Olanzapine and Rispridone on lipid level and blood glocuse and other complications in patients with psychotic disorders. This clinical trial-double blinded study, patients with psychotic disorders were randomly categorized into two groups. Group one treated with Olanzapine and other with Rispridone. All the subjects were initially assessed for blood sugar and lipids, and in the case of normal, they were randomly assigned to two groups in a double- blinded method to be treated with Olanzapine or Risperidone. Blood sugar and lipids tests were performed for all subjects at the 1st week and 3 months after initiation of therapy. Other complications were assessed too, then the data were analyzed using SPSS software. The results of the study indicated that the levels of cholesterol, triglycerides and blood sugar rose significantly at the 1st week and third month after beginning the treatment. Increase of cholesterol and triglyceride in the Olanzapine and Risperidone groups was significant, while blood sugar level showed no significant difference in these two groups. Other side effects including restlessness, impotence, weight again, edema and drowsiness were significantly different between the two groups. Based on the findings of this study and the emphasis of other related studies on the metabolic changes of the body resulting from atypical antipsychotic drugs, it is suggested that these drugs should be prescribed for high risk patients with great care and cautions