ABSTRACT
Background: high lipid serum level was a risk factor for cardiovascular disease. This study was performed to evaluate the effects of Lovastatin and exercise on hyperlipidemic patients at Kashan Shahid Beheshti Hospital during 2005-6
Materials and Methods: this randomized clinical trial study was carried out on hyperlipidemic patients [age>30 years]. After registering the personal data of the patients the participants were selected based on the inclusion criteria [HDL<35 mg/dl, LDL >/= 160 mg/dl, TG >/= 200 mg/dl, Chol >/= 200 mg/dl]. The Lovastatin group [40 mg/daily] and the exercise group [waking 35 minutes/day, 3 times a week]. The clinical tests were repeated for six consecutive weeks. Data were analyzed using t-Test, Wilcoxon Signed Rample Test, Kolomogorou-Smirnov Test, Mann-Whitney Test, levens Test
Results: from Ninety-six out of 150 cases were hyperlipidemic signifying that only 80 [59 male, mean age 55.12 +/- 8.4 case and control 55.35 +/- 9.2 years] out of 150 hyperlipidemic patients were qualified for the study. The mean decrease in TG level between the Lovastatin and exercise groups were 21.4 [P=0.2] and 20.5 mg/dl [P=0.2], respectively. The mean decrease in cholesterol level between Lovastatin and exercise groups were 41.3 and 1.5 mg/dL [P=0.001]. The mean decrease in LDL level between Lovastatin and exercise groups were 35.8 and 8.5 mg/dl [P<0.001], respectively. Finally, the mean increase in HDL level between Lovastatin and exercise groups were 5.4 and 0.4 mg/dl
Conclusion: exercise may be effective for decreasing the LDL. While Lovastatin could decrease the total cholesterol TG and increase HDL levels, using a combination is recommended for hyperlipidemic patients