[Aggressive evolution of dermatofibrosarcoma]

Malignen change in dermatofibrosarcoma protuberans is a rare phenomenon. We present one case. A patient operated for local recurrences of dermatofibrosarcoma. The histopathological study showed a fascicular and highly cellular histological pattern in the dermis, with important mitotic activity. Sometimes the nucleus was central chow small indentations produced by multiple small vacuoles like a lipoblast, with an extensive capillary network appearance the diagnosis of liposarcoma was proposed. Malignen change of dermatofibrosarcoma is defined by it herringbone architecture, hypercellularity, and increased mitotic rate. Occasionally, can lead to misdiagnosis with other spindle-cell tumors especially liposarcoma which has a worse prognosis. Multiple sampling and immunohistochemistry with antibody CD34 help to establish the right diagnosis. The degree of aggression is related to the histological grade and of sarc omatous transformation. The prognosis of the transformed dermatofibrosarcoma is more aggressive than the classic than one in liposarcoma

Efficacy and safety of ginger to reduce nausea and vomiting of pregnancy: a systematic review and meta-analysis

To assess the efficacy and safety of ginger [rhizome of Zingiber officinale] to reduce severity of nausea and numbers of vomiting in early pregnancy. MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL and SID databaseswere searched for relevant sources. Randomized trials of oral ginger in comparison with placebo for nausea and/or vomiting in early pregnancy were selected. Two reviewers assessed the trial quality and extracted the data independently. Five trials met the inclusion criteria to assess the efficacy. Based on these trials, there was a significant reduction in severity of nausea after taking ginger compared with placebo [Pooled SMD= 0.882, 90% confidence interval 0.267 to 1.496]. Also there was similar effect in reducing number of vomiting [Pooled SMD= 0.631, 90% confidence interval 0.433 to 0.829]. In addition, there were 5 trials or observational studies which had assessed the potential fetomaternal side effects of ginger. There was no supporting evidence for increasing pregnancy complications after using Ginger. Based on the current evidences, Ginger reduces the severity of nausea and frequency of vomiting in early pregnancy. There are considerations about adverse effects, but they are not supported by the clinical evidence. It seems that ginger could be used during pregnancy in therapeutic doses [almost 1 gr per day] for limited durations

Hepatoprotective effect of silybum marianum [L] gaertn and glycyrrhiza glabra L. in the rats

One of the major role of liver is metabolism of xenobiotics and detoxification. But sometimes during metabolism of xenobiotics produce active and more toxic agents which cause liver damage and disease. Use of nature products from vegetables. In the treatment of diseases and liver diseases have a long history, especially in Eastern medicine in this study we have investigate the protective effects of polyphenolic extracts of Silybum marianum and Cichorium intybus. Liver damage induced with hepatotoxin, thioacethamide. Extracts was injected every day for a duration of 3 days, to rats, at a doses of 25 mmg/kg body weight together with thioacetamide at a doses of 50 mg/kg body weight. In order to investigate the hepatoprotective effect of extracts against thioacetamide activities of serum aminotrasferases [SGOT and SGPT], alkalline Pbosphatase bilirubin, Na[+] and K[+] were measured.Activities of serum aminotrasferases [SGOT and SGPT], alkaline phosphatase and bilirubin were decreased significantly to rats treated with extracts compared to thioacetamide group. The results showed potent protective effects of these extracts against the thioacetamide induced hepatotoxicity that are due to antioxidant effect of polyphenolic compound

Kemzyme and laying hen performance

An experiment was conducted using 120 brown Shaver laying hens to determine if an enzyme preparation "Kemzyme" would improve laying hen performance. Kemzyme was added at 0, 0.05 and 0.1% levels to a basal layer diet composed of corn, soybean meal, wheat bran, concentrate and limestone. The experimental diets were fed at a rate of 110 g/hen/day during five 28-day periods. Addition of Kemzyme at 0.05% level improved egg number and egg mass without affecting egg weight. The higher level of Kemzyme [0.1%] did not prove to be of additional benefit in supporting egg production. No alteration was recorded in egg weight, egg height, shell thickness, yolk weight, albumen weight and shell ash% by either dietary levels of Kemzyme supplementation