ABSTRACT
In recent years there have been noticeable changes in diagnosis and treatment of colon disorders by colonoscopy and direct vision. Along with its international development, this useful equipment is being used in Iran to treat various disorders. It should be mentioned that there are no exact statistics of these disorders to date. This study was done with aim of evaluating the diagnostic findings in patients undergoing colonoscopy in Qom during 2007-2008. This descriptive-cross sectional study was done on 500 patients having referred to colonoscopy ward of Hazrate-e-Masoome Hospital in Qom. After colonoscopy, patient data were entered into a special questionnaire and then pathologic findings were added to it. The data were taken for statistical analysis. Out of 500 patients undergoing colonoscopy 279 were male [55.8%] and 221 female [44.2%]. In all groups and both sexes the most common reason for carrying out colonoscopy was abdominal pain [46.6%] rectorrhagia [41%]. As regards diagnosis, a total of 199 cases [39.8%] of all 500 colonoscopies had normal colonoscopy,124 cases [24.8%] had hemorrhoid, 64 cases [12.8%] had polyp, 55 cases [11%] had inflammatory bowel diseases [IBD], 30 cases [6%] had tumor, 17 cases[3.2%] had diverticulosis and 12 cases [2.4%] had solitary rectal ulcer. There was a significant relationship between abdominal pain and tumor, polyp and diverticulosis. [p<0.001] There was also a significant relationship between age and the aforementioned disorders. [p<0.001] Based on the findings of this study, the prevalence of cancer and IBD is higher in men diverticulosis is higher in women. The highest prevalence of IBD was in the age group of 21-30 years. With an increase in age, the incidence rate of this disease decreases
ABSTRACT
Hepatitis A and E are among the most important etiological factors of acute hepatitis, which can lead to fulminant liver disease and death. The aim of this study was to determine the prevalence of hepatitis A and E in the east of Golestan Province, Iran. Eight hundred inhabitants of Gonbad City and Ghamar Ghozi Village from Kalale district were randomly selected for the study. Hepatitis A virus Antibody [Anti HAV] and Hepatitis E virus Antibody [Anti HEV] were checked by ELISA method. A total of 697 subjects [441 females] with a mean age of 43 +/- 15.1 years participated in this study. A total of 687 [98.6%] and 82 [11.8%] persons had positive Anti HAV and Anti HEV, respectively. This research is the first study on the prevalence of hepatitis A and E in the general population of Iran, which shows that HA V infection is pandemic and hepatitis E is common in the area
ABSTRACT
Febrile convulsion is one of the most common CNS disorders of children for which several predisposing factors have been mentioned.The objcective of this study was to determine predisposing factors and analysis of the demographic characteristics of children with febrile seizures. Patients group consisted of 115 children aged 5-60 months.Control group was 345 healthy children with the same age and sex. According to demographic charactristics, positive correlation between mean weight and family history for febrile seizure; were statistically significant. where as differences between head circumfrence, height, breast feeding, birth APGAR score and multi vitamins and Iran supplement in patients and control group were not statistically significant. We concluded that febrile convulsion was more common among children with higher weight and family history of febrile seizures
Subject(s)
Child, Preschool , Female , Humans , Infant, Newborn , Male , Demography , Body Weight , Risk FactorsABSTRACT
Gastric cancer is a relatively common cancer that can metastasize to multiple organs such as liver and the biliary tract. The patient is a 60-year-old woman who was admitted for severe abdominal pain, icterus, rised liver enzymes and a mass at the bifurcation of the common bile duct in MRCP [Magnetic Resonance Cholangio pancreatography] and was diagnosed as a case of primary colangiocarcinoma [Klat skin]. Patient was scheduled for stenting. Because of aggravation of abdominal pain. Upper GI endoscopy was performed and an extensive tumoral mass was found from body down to the pylorus of stomach. The pathology report of biopsies obtained from mass was Signet Ring cell adenocarcinoma of stomach which had metastasized to the biliary tract
Subject(s)
Female , Humans , Middle Aged , Stomach Neoplasms/pathology , Cholangiocarcinoma/diagnosis , Neoplasm MetastasisABSTRACT
Bakground: Granulocyte colony-stimulating factor [G-CSF] is a cytokine that stimulates hematopoiesis and induces proliferation and differentiation of granulocyte progenitor cells as well as production of bone marrow neutrophilic granulocyte colonies. Nowadays, human recombinant G-CSF[hr G-CSF] is used for the treatment of chemotherapy- and radiotherapy-induced neutropenia, and also in patients with bone marrow transplantation. A cDNA of human G-CSF [hG-CSF] was synthesized by PCR from recombinant cloning vector, with two altered nucleotides for increasing mRNA stability and overexpression, then inserted into a pET expression vector under the control of T7 promoter and cloned in E. coli strain BL21 [DE3]. After culture and induction of recombinant E. coli with IPTG, we achieved a high level expression of the hG-CSF, where it represented approximately 35% of the total protein as determined by SDS-PAGE and confirmed by western blotting with polyclonal and monoclonal hG-CSF antibodies. rhG-CSF was produced in a significantly high quantity with a yield of 35% of total protein as determined by SDS-PAGE. Since it is easily obtained by simple purification steps, it may be cost-effective, even on an industrial scale