ABSTRACT
To compare the morphology and function of corneal enthothelial cell in early postoperative period after phacoemulsification with infusion or bolus intracameral adrenaline. In this prospective randomized study, 71 eyes of 71 patients scheduled for phacoemulsification were randomly assigned to two groups: one group [31 eyes] received bolus intraocular adrenaline at 1/10,000 concentration and the other group [30 eyes] received adrenaline infusion at 1/1,000,000 concentration intraoperatively. Pre- and one month postoperatively, a complete ophthalmologic examination as well as endothelial evaluation with ConfoScan III was performed. Effective phaco time [EPT] and pupillary condition during the surgery were recorded. Differences between the two groups were not statistically significant in demographic characteristics, lens opacity and EPT. Endothelial cell density was 2737 +/- 321 in the bolus group vs 2742 +/- 426 in the infusion group preoperatively [P=0.1]. After one month, the rate of cell loss was 7.21% in the infusion group and 8.87% in the bolus group [P= 0.13]. Pupil diameter was >6 mm in 48% of the infusion group vs 33% of the bolus group [P=0.5]. Adrenaline was safe at the studied concentrations and there was no significant difference between bolus and infusion routes of administration in terms of effects on pupil and endothelial cells