Comparison of gastric adverse effects of aspirin and celecoxib before and after eradicating Helicobacter spp. infection in dogs

The present study was carried out to determine whether Helicobacter spp. infection in dogs could affect lesions caused by the non-steroidal anti-inflammatory drugs [NSAIDs], aspirin and celecoxib. Thirty asymptomatic mixed-breed dogs were used for this study. Gastric biopsies were taken via gastroscopy and evaluated by polymerase chain reaction [PCR] and rapid urease tests [RUT]. Helicobacter spp. was detected in all specimens. The infection was completely eradicated in 15 dogs by a three-drug regimen for 21 days [amoxicillin, clarithromycin and omeprazole]. Each Helicobacter-positive and -negative group was then divided into three subgroups treated with aspirin, celecoxib and placebo for 14 days. Dogs in the different subgroups were compared by sequential gastroscopy on days 0, 3, 7, 14 and 21 [a week after drug cessation]. The results show that selective COX-2 inhibitors are better tolerated than conventional non-selective NSAIDs in dogs in terms of their side effects; however, these drugs should be administered with caution. Unlike what is advised in medical practices in humans, it seems that the eradication of non-pylori Helicobacter spp. from the stomach is not necessary prior to administrating NSAIDs in dogs

Chlamydia trachomatis and cervical intraepithelial neoplasia in married women in a Middle Eastern community

The objective of this study was to determine the association between vaginal Chlamydia infection and cervical intraepithelial neoplasia [CIN]. Data were collected in a case-control study for 60 patients with CIN in biopsy and 85 control subjects with normal colposcopy and biopsy. Serum antibodies to C. trachomatis were associated with an increased risk for CIN [odds ratio [OR] = 7.3; 95% confidence interval [CI] 1.5-35.2]]. There was also a significant association between presence of inclusion bodies for C. trachomatis and CIN [OR = 5.5; 95% CI 2.4-12.4]. These results indicate a strong association between CIN and chlamydial cervicitis

[Risk factors for recurrent preterm delivery in three university hospitals]

Preterm labor is defined as delivery before 37 weeks of gestation. Recurrence of preterm labor in future pregnancies is 6-8%. History of preterm labor is a strong risk factor for future preterm labor. Preterm labor is the leading cause of neonatal mortality in developed countries, but permanent morbidity in these premature neonates has many side effects for the newborn as well as their family members and society. For this reason we conducted a survey to identify risk factors for recurrent preterm delivery among primiparous women with previous preterm delivery. This prospective case-control study included patients from three university hospitals, namely Imam Khomeini, Shariati and Mirza Koochakkhan Hospitals, all in Tehran, Iran. Subjects, including 539 primiparous women who delivered preterm [22-36 weeks], were divided into two groups: 47 had a second preterm delivery [study group] and 492 had first preterm delivery [control group]. Exclusion criteria were induced preterm delivery due to medical indications in mother and primigravid. Data collection and analysis was performed using SPSS 10 and t-test and chi[2] test were used to analyze the significance of the results. From a total of 6,537 deliveries, we found 539 cases of preterm delivery, among which 47 cases were identified as recurrent preterm delivery. The control group was composed of 492 deliveries. The recurrence of preterm delivery was 8.7%. Uterine anomaly, cardiovascular, renal and thyroid disease in mother and blood group A had a significant correlation with recurrent preterm delivery. Expectant mothers with uterine anomalies, cardiovascular, renal or thyroid diseases or group A blood type should receive extra care, observation and instructions in order to limit the risk of preterm delivery and its subsequent effects