ABSTRACT
Background: To compare the dosimetric coverage of the planning target volume [PTV] and the dose delivered to the main Organs at Risk [OARs] in 5 and 7-field techniques of Intensity Modulated Radiation Therapy [IMRT] in patients with local prostate cancer
Materials and Methods: Twelve patients with local prostate cancer underwent 5 and 7-field IMRT planning. The delivery of IMRT was carried out using the sliding technique. The dose coverage for PTV was designated to >/= 98% of the PTV covered by 95% of the prescribed dose. Dose conformity was evaluated by comparing the volume of nontarget tissue receiving maximum, and average of the prescribed dose and the dose of 33%, 50%, and 66% of the volumes on both planning sets. For target, this evaluation was made with comparing the Conformity Index [CI] and Inhomogeneity Index [HI]. In addition, we compared the monitor units used for dose delivery in both planning techniques
Results: All the 5 and 7-field IMRT plans differed slightly in the measured parameters, and none of them have statistically significant differences with each other except for the monitor units where significant differences were observed in favor of the 5-field IMRT plans [p=0.000]. In all of the 5-field IMRT plans the mean dose delivered to OARs were very similar or less than that of the 7-field plans
Conclusion: In comparison to the 7-field technique, the 5-field IMRT technique has resulted in improved IMRT dose conformity, homogeneity, and lesser MUs used for radiation therapy. However, this difference was not significant
ABSTRACT
Metabolic syndrome [MS] is a risk factor for type 2 diabetes mellitus and cardiovascular disease. Limited information is available about the prevalence of the metabolic syndrome in rural areas of Iran. A total 1402 adults [1042 females and 360 males], aged between 18-90 yrs, participated in a community-based cross-sectional study. Prevalence of metabolic syndrome was determined by the definition of the National Cholestrol Education Program Adult Treatment Panel III [NCEP ATPIII], and results were compared with those based on the revised ATPIII and International Diabetes Federation [IDF] definitions. Overall prevalence of ATP III defined metabolic syndrome was 25.6% compared to 29% and 33% using the revised ATP III, IDF definition respectively. The results of multiple logistic regression model showed after adjusting for age, sex, Body Mass Index [BMI], marital status, and education level, there was no difference between men and women for metabolic syndrome [P=0.2] by ATP III and revised ATP III definitions while prevalence of metabolic syndrome was 1.97 times greater in women versus men [95% Cl: 1.4 - 2.7, p< 0.001] by the IDF-definition. Sex-adjusted prevalence of metabolic syndrome [by three definitions] increased 1.05%, for each one year increase in age [95% Cl: [1.04-1.06]]. In the current study, low serum High Density Lipoprotein Cholesterol [HDL-C] was the most common component of metabolic syndrome, while high fasting plasma glucose was the least common. These results show that the metabolic syndrome is prevalent in rural areas and interventional strategies should be considered for weight reduction and treating components of metabolic syndrome in this population