ABSTRACT
Background: Apoptosis is a type of programmed cell death that occurs by a series of Intercellular messages under Specific conditions
Objective: The aim of present study was investigat role of the Adiantum capillus veneris extract on modulation of Bax and Bcl2 Apoptotic markers of lung in trained rats and exposed to hypoxic stress
Methods: 14 male Wistar rats were sampels of This study, that were Quite healthy and had no disease history [4 weeks old, 72 +/- 9 gr weight] that exposed to hypoxic Environment for 3 weeks after 6 weeks high intensity interval training. Half of the samples were taken 500 ml Adiantum capillus veneris extract Per kilogram of body weight in During exposure to hypoxia environment. Finally, lung tissue was extracted for Immunohistochemical Measurements
Results: Statistical analysis showed that Adiantum capillus veneris extract Consumption for 3 veeks in samples that exposed to hypoxia, Significantly reduced Bax protein Expression of Pulmonary alveolar [P 0.05] and Significantly reduced Bax /Bcl2 Ratio[P
Conclusion: It seems that Adiantum capillus veneris extract, Could possibly modulat Pro-apoptotic and anti-apoptotic proteins expression in pulmonary alveolars that exposed to hypoxic Environment that likely has Considerable effects to Inhibition of lung Pro-apoptotic reactions Due hypoxia
ABSTRACT
Background and aim: Infertility is a major reproductive health problem that affect 10%-15% of couples. According to the World Health Organization, there are currently 50-80 million infertile couples in the world. Physical activity is a life style factor with possible positive or negative effects on reproductive. The aim of this study was to compare the physical activity of fertile and infertile couples in Kermanshah, Iran during 2013
Materials and Methods: This was a descriptive comparative study. The case group consisted of 118 infertile couples attending Motazedi Infertility Center. One hundred and eight fertile couple attending to six public health centers in Kermanshah, Iran, were the controls. The sampling method was convenience sampling. Data were collected by a questionnaire. The questionnaire was consisted of two section. The first section was demographic and fertility characteristics and the second section was international physical activity questionnaire. The data is presented by descriptive statistics and analyzed with logistic regression, independent t-test, chi-square, and gamma tests using SPSS v16
Results:The result of this study showed that the majority of fertile women[86.1%], infertile women[73.1%], fertile men[87%] and infertile men[96.3%] had moderate level of physical activity. There was a significant difference between fertile and infertile men and women in terms of physical activity. The fertile and infertile couples, also, have significant difference in physical activity[P<0/05]
Conclusions: Given the importance of physical activity on reproductive health and significant difference of physical activity between fertile and infertile couples in this study, it seems that more attention should be paid to lifestyle behaviors, especially in infertile couples
ABSTRACT
Ca is the most important minerals in the body that plays a key rols in the physiological activities, anzymatic reaction and the regulation of myocardial contraction and relaxation. Ca deficiency causes the heart failure and decrease cardiac contractility. To determine the effects of long-term dietary calcium deficiency on the heart function of layer hens based on the electro- and echocardiography. Ninety Hyline W36 hens were kept for 21 weeks and fed by rations with different amounts of calcium. At 20, 28 and 36 weeks of age, electrocardiographic, echocardiographic and post-mortem left ventricular parameters were assessed. S wave amplitude was significantly [p<0.05] increased in the Ca-deficient group II [in lead II] at 36 weeks of age in compared to control. There were also elevations of the QRS wave amplitudes in 28 and 36 weeks of age at two Ca-deficient groups [leads II, III, aVR, aVL and aVF] but were only significant [p<0.05] in Ca-deficient group II [leads II and aVF] in compared to control. Left ventricular free wall diameter at end-systole were significantly [p<0.05] increased in the Ca-deficient group II at 28 and 36 weeks of age compared to the control group. Inter-ventricular septal diameters at end-systole were decreased in two Ca-deficient groups at 28 and 36 weeks [p<0.05]. Left ventricular free wall diameter at post-mortem were significantly [p<0.05] increased in two Ca-deficient groups at 36 weeks of age compared to the control group. From these results, it can be suggested that long-term dietary calcium deficiency alters in electro- and echocardiographic parameters, which could reflect pathological left ventricular hypertrophy in the laying hens
ABSTRACT
In traditional medicine of west of Iran, Falcaria vulgaris [Ghazzayaghi] were used for many purposes such as treatment of skin ulcer and gastric disorders. The extract of falcaria vulgaris showed prominent protective effect on gastric mucosa against ethanol adverse effects in our pervious study. The aim of this study is to evaluate the protective effect of hydroalcoholic extract of F. vulgaris on aspirin-induced gastric ulcer in rat. 24 young male rats [NMRI strain], with the weights of 180-230 gr divided into four groups [6 Rats/group]: Case group, received 150 mg Falcaria vulgaris extract /kg/day, Control negative group, received 1ce DW /kg/day, Control positive groups received 5 mg omeprazole /kg/day, ASA solvent groups received 150 mg falcaria vulgaris extract /kg/day, Gavage of the above mentioned doses continued for 14 days. Animals were deprived of food from day ten for 48 hour and the three first groups received ASA [200 mg/kg/day] in 1cc solvent [carboxymethyl cellulose] orally for 3 days [12-14] and the last group received only ASA. Solvent 3 hours after the last dose, Animals were killed and their stomachs were dissected. Based on the size of ulcers and their mean number, the microscopic ulcer-index and cure rate were assessed for every stomach by use of stereomicroscope and graticule. In order to study ulcer formation and its healing, microscopic slides from the lesions were prepared. Data were analyzed by one-way ANOVA and Tukey test. F. vulgaris extract [150 mg/kg/day] significantly [p<0.01] decreased stomach ulcer index and also increased cure rate to 91.73%, and 90.25% in comparison to negative control and positive control groups respectively. Histologic survey confirms macroscopic findings. F. vulgaris extract has significant beneficial effects on the healing of aspirin induced gastric ulcer