ABSTRACT
Statement of Problem: Basal cell carcinoma [BCC], the most common skin cancer, is a locally invasive malignant epidermal tumor with ulceration and destruction of underlying structures
Purpose: The purpose of this study was clinicopathological evaluation of BCC in the state and the private pathology centers in Hamadan province during 1990-2010
Materials and Method: In this retrospective study all histopathologically proven cases of BCC were reviewed and the related information including age, gender, place of residency and number of tumors for the patients alongside with the site of occurrence, size, histopathological and clinical type of the lesions were collected and then statistically analyzed, using SPSS software
Results: A total of 804 incidents of BCC were diagnosed in 746 patients [296 females and 450 males] with the most affected site being in the head-face [84.8%], neck [2.6%], trunk [1.6%] and limbs [0.9 %] and 10.1% cases with unknown site. The mean age for the patients was 61.77+/-13.75 years [63.07+/- 13.44 for males, 59.81 +/- 14.01 for females] and the highest frequency [27.2%] occurred among 60-69 years age group. Nodular type was the most common clinical and histopathological BCC lesions studied whereas the mean size of the lesions was 15.67 +/- 11.06 mm with more frequency rate in urban than rural regions
Conclusion: This study focuses on the survey of BCC in Hamadan province but regarding to insufficiency of the data collected by state and provincial pathology centers about the BCC cases reported; it is highly recommended to apply comprehensive questionnaire, which are designated by skillful professionals who are familiar with the lesion nationally
ABSTRACT
Statement of Problem: Oral biopsy is important in the definite diagnosis of oral and maxillofacial lesions. This procedure as well as other laboratory services is prone to errors affecting the patients' safety
Purpose: The purpose of this study was to evaluate pre-analytical biopsy specimen errors in the Oral Pathology Laboratory of Hamedan School of Dentistry, west of Iran
Materials and Method: Ninety-one oral biopsy samples, obtained from departments of oral and maxillofacial surgery [34 samples, 37.3%], oral medicine [22 samples, 24.3%] and periodontics [10 samples, 10.9%], as well as private offices [16 samples, 17.6%] and hospitals [9 samples, 9.9%] were received and evaluated in the Oral Pathology Laboratory of Hamedan School of Dentistry considering pre-analytical errors
Results: The errors in the request forms included unmentioned names of patients [7.7%], age [3.3%], clinical history [4.4%], site of biopsy [10.9%], differential diagnosis [18.7%] and the name of the requesting clinician [8.8%], as well as lack of radiographs [4.4%] and previous biopsy results [2.2%]. Use of inappropriate fixative [5%], and specimen-containers with non-proportional volume [3%], and their small size inlets [3%] was also reported. Non-standard containers were seen in 19% of the cases, and mislabeling errors [31 missed, 2 incomplete defects, and 1 incorrect] in 34% of the cases. Of 105 specimens, 6.67% were small in size, 1.90% superficially removed, and 0.95% had been traumatized. Out of the 5 containers with more than one specimen, 4 containers did not have any markers
Conclusion: Considering the biopsy errors in the study specimens, training and surveillance to reduce the frequency of such errors seems necessary
ABSTRACT
Statement of Problems: An oral biopsy is essential for definitive diagnosis of oral lesions, and for planning the appropriate treatment. Any fault that happens in biopsy procedures may result in diagnostic errors by pathologists. Thus, inadequate awareness of dentists and patients about biopsy is a significant concern for both of them
Purpose: The aim of this study was to compare the senior students of dentistry and dental medical doctors' knowledge about harvesting and handling of oral biopsies in Hamadan city. [2009-2010]
Materials and Method: This cross-sectional study was conducted by using a questionnaire. The data were collected and analyzed through SPSS, version 15. Independent t-test was employed to determine the differences between groups
Results: Of the total 152 collected questionnaires, 42 and 110 were completed by dental students and general dentists, respectively. Accurate responses by the students [72.48+/-10.76%] was significantly higher than those of the dentists [62.22+/-14.99 % ; p =0.00]. There were no significant differences in the correct responses given by female [75+/-10.11 %] and male [70.20+/-11.05 %] students and also between female [61.11+/-14.66 %] and male [62.67+/-15.19 %] dentists [p >0.05]. Among general dentists, the differences of accurate responses between those with professional experience <10 years [62.44+/-15.64 %] and those with the professional experience >10 years [61.82+/-13.91 %] were not significant; [p =0.83]
Conclusion: This study revealed that dental medical doctors' awareness regarding harvesting and handling of oral biopsies is lower than that of the students of dentistry. Moreover, gender and professional experience did not affect the level of knowledge. Consequently, there is a need for further training in this respect for dental medical doctors
ABSTRACT
Statement of Problems: Bisphosphonates are a class of agents used in treating a variety of bone diseases, including osteoporosis, multiple myeloma and hypocalcemia due to malignancy. Despite the benefits related to the use of these medications, in recent years, numerous cases of bisphosphonate-related osteonecrosis of the jaws [BRONJ] of patients treated with oral/IV bisphosphonates have been reported. The BRONJ phenomenon is a serious complication, presenting as an exposure of alveolar bone either spontaneously or secondary to invasive oral surgical procedures
Purpose: This review aimed to warn dentists and dental specialists about BRONJ and propose guidelines for diagnosis, staging, management and treatment selection based on the available data and the authors' experiences
Conclusion: All the patients treated with oral or IV bisphosphonate therapy are at risk of BRONJ. Suggested guidelines for these two applied forms of bisphosphonates vary. In IV bisphosphonate therapy, all dentoalveolar surgeries are contraindicated and should be avoided. However, the indications are more controversial in the cases of bisphosphonates administered via the oral route and are related to the duration of treatment