ABSTRACT
Preservation of facial nerve is a real challenge in parotidectomy. Total conservative parotidectomy and superficial parotidectomy are the commonly practised operations for parotid diseases. Twelve patients have undergone total conservative parotidectomy and 52 patients have undergone superficial perotidectomy with preservation of integrity and function of the facial nerve and its branches. Fifty-eight patients were suffering from neoplastic conditions of which 46 had pleomorphic adenoma, 7 had muco-epidermoid carcinoma, 3 had carcinoma ex-pleomorphic adenoma, and 2 had adenoid cystic carcinoma. Non-neoplastic conditions were seen in 6 cases of which 3 had chronic parotitis and 3 had congenital parotid fistula. The aim of the study was to observe the efficacy of preservation of facial nerve in parotidectomy done in 64 patients.
Subject(s)
Adolescent , Adult , Aged , Child , Facial Nerve Injuries/prevention & control , Female , Follow-Up Studies , Humans , Intraoperative Complications/prevention & control , Male , Middle Aged , Otorhinolaryngologic Surgical Procedures/methods , Parotid Diseases/surgery , Parotid Gland/innervation , Prospective Studies , Treatment OutcomeABSTRACT
This research work has been designed to show the CNS neurotransmitter receptors activity especially anticonvulsant and sedative activity of ethanolic extracts of Centella asiatica on a number of pharmacological model in mice. Phenobarbitone and diazepam induced sleeping time model was used to demonstrate the sedative activity and the ethanolic extract of Centella asiatica significantly prolonged [p<0.00 1] phenobarbitone and diazepam induced sleeping time in mice as compared with the control suggesting possible interaction with GABA-BNZ receptors complex to mediate sedative action. According to Nikethamide induced convulsion model where tonic and clonic convulsion as well as mortality and morbidity rate was considered and the extracts of Centella asiatica were shown to be delayed the Nikethamide [300 mg/kg, i.p.] induced convulsion indicating a possible action involving GABA and glutamate receptors to mediate anti-convulsant effects. Therefore, this plant may have the potential in the treatment of various CNS disorders like anxiety, depression, insomnia and convulsion as well as this data can also be used in the development of novel psychopharmatherapeutic agents