ABSTRACT
To determine the prevalence of keratoconus [KCN] in patients with mitral valve prolapse [MVP]. This descriptive study was conducted on patients with MVP at Shahid Rajaei Hospital during 2003-2004. Corneal topography was performed in 392 subjects with absolute mitral valve prolapse based on Perloff's major criteria. Orbscan was carried out in suspected KCN cases. Results: Patient consisted of 247 men [63%] and 145 women [37%] with mean age of 37.27 +/- 11.29 years. The diagnosis of two topographically KCN suspect patients was not confirmed with Orbscan. Positive family history of keratoconus in first-degree relatives was found in three patients. No cases of keratoconus were found. This study suggests that the prevalence of KCN in patient's with MVP could be less than previously reported. A large multicenter study is needed to detect the association of these disorders. Genetic studies are suggested