[Comparison of sequential and routine four drugs therapeutic regiments in Helicobacter pylori eradication]

Antibiotical resistance to Helicobacter pylori reduced the eradication rates. This study was done to compare the sequential comparison of sequential and routine four drugs therapeutic regiments in Helicobacter pylori eradication. In this double blind clinical trial study 160 chronic dyspepsia patients randomly divided into 2 groups of sequential and routine four drugs therapeutic regiments. We performed invasive tests for H. pylori in patients who underwent gastroduodenoscopy. 160 patients who were diagnosed as H.pylori-positive by histological evaluation were selected for the trial. A 14-day sequential regimen [Omeprazole, Amoxicillin, each administered twice daily for the first 5 days, followed by Omprazole, Clarithromycin and Urazolidon, each administered twice daily for the remaining 9 days. 14-day 4 drug therapy, Omprazole, Clarithromycin, Amoxicillin and Bismoot each administered twice daily. 5 weeks after treatment urease breath test [UBT] was preformed. The recovery was seen in 50.9% and 49.1% in sequential and routine four drugs therapeutical treatment, respectively. The recovery of patient with severe H. pylori infection was non-significantly higher in sequential regiment [64.7%] than four drugs regiment [41.2%]. In comparison to four drugs, sequential therapy was significantly more effective in patients with sever gastritis [87.5% vs. 25%, p<0.05]. The eradication of H. pylori infection particularly in severe gastritis is preferred by sequential therapeutical regiment

[Seroepidemiology of VZV in the young adults referring to Rasoul-Akram hospital in Tehran]

Varicella-Zoster virus causes chicken - pox, which is a mild disease in children. However, in adolescents and adults between 20 to 40 years of age, it may be severe with visceral involvement such as pneumonia and hepatitis. In this study the level of anti VZV antibody in young adults was determined. Compatibility of the history of varicella with presence of varicella antibody in this population, considering sensitivity, specificity, predictive positive and predictive negative values, was assessed. This cross-sectional study included 400 healthy young adults. The enzyme immunoassay was used to determine the titer of IgG antibodies against VZV in the sera. Statistical analysis of the data was performed by means of chi2 test. A total of 400 young adults between 20 and 40 years of age were examined and 313 [78. 25%] of them were found to be seropositive. Sero-positivity was more significant in the females [P=0.048]. There was no statistically significant difference in the antibody titer between different age groups [P=0.82]. Correlations of sensitivity and positive predictive value of history of varicella with presence of antibody in the sera were 89% and 95% respectively. The results of this study showed a significant number of young adults are susceptible to infection and extensive screening and sero-prevalence studies are needed to make decision about mass vaccination in children in Iran