High energy states of tolnaftate

Solid dispersions of tolnaftate were prepared using polyvinylpyrrolidone [PVP], polyethylene glycol 20,000 [PEG], urea, thiourea, sucrose and glucose. The dissolution studies showed that the presence of water soluble polymers enhance the dissolution rate of the drug. The amount of tolnaftate released after three hours increased more than 33 times and 25 times on using PVP and PEG respectively as compared with the dissolution of the control untreated powder. The solid dispersion systems were examined using differential thermal analysis [DTA] and showed a reaction at higher temperature only. The dissolution rate was also increased in presence of surface active agent. This may be due to better wetting of the power in the solution presumably lower surface tension. The effect of the used polymers and surfactants on the solubility of tolnaftate was also investigated

Availability of piprofen from tropical vehicles

Films of ethyl cellulose [EC], hydroxy propyl methyl cellulose [HPMC] and mixture of them were investigated as a transdermal delivery system for pirprofen in comparison with Pluronic F 127 and carboxy methyl cellulose [CMC] gels. The results were given in details