ABSTRACT
This study included 21 patients with chronic active hepatitis C virus [CAM. CV] Group I and 18 patients with liver cirrhosis group II, both proved by liver biopsy. Only patient with normal serum creatinine were included in this study, and urinary creatinine was used to normalize the urinary TGF - B1 level.Twenty healthy individuals of comparable age and sex constituted the control group.This study showed that the urinary TGF-BI level was significantly higher in group 1[5.52 +/- 6.63ng/mg creatinine] than in the control group [0.185 +/- 0.15 ng.mg creatinine] ,with P value < 0.001 . As regards the Histological Activity Index [HAI], there was a significant difference between urinary level of TGF-Bi in patients with mild disease [2.8 +/- 2.4 ng/rng creatinine] and those with moderate to marked disease [11.3 +/- 8.5 ng/mg creatinine] with P value <0.05 . Urinary level of TGF-BI was also significantly higher in group II [3.45 +/- 4.18 ng/mg creatinine] than in the control group [0.185 +/- 0.15 ng/mg creatinine] with P value < 0.001. It was also higher in cirrhoticpatients with Child - B to C [9.3 +/- 4.8 ng/mg creatinine] than in those with Child - A [1.81 +/- 1.86 ng/ing creatinine] with P value < 0.05 .In conclusion, urinary TGF - B1 level may be used as a marker for hepatic fibrogenesis , and a higher urinary TGF - Bl levels correlate with more severe liver disease