Synthesis and antimicrobial activity of novel monosaccharide [quinolin-4-yI] hydrazones, oxadiazoles, thiazolidinones and pyrazoles

Several quinoline derivatives appear to be of interest due to their biological and pharmacological activities. The present work deals with the synthesis of some new quinolines incorporated with monosaccharidehydrazone, oxadiazole, thiazolidinone, and/or pyrazole moieties at 4- position, starting with 2-[6-bromo-2-methylquinolin-4-yloxy] acetohydrazide [4] as the key intermediate. Some examples of the new compounds showed moderate inhibitory effect on the growth of G+ve, G-ve bacteria, yeast and fungi

Synthesis and in vitro anticancer evaluation of some new [tetrahydronaphthalen-2y1] nitrogen heterocycles

Condensation of 2-acetyltetralin I with two aromatic aldehydes afforded the respective chalcones 7a,b. When the reaction of 1 with aldehydes was conducted in presence of ethylcyanoacetate and/or malononitrile and ammonium acetate, it yielded tetrahydronaphthalenyl nicotinonitriles of types 3 and 4. Chalcones 7a,b yielded 2-pyrimidinones 8a,b, 2- thiopyrimidines 9a,b and pyrazoline derivatives 10a,b upon reaction with urea, thiourea and hydrazine, respectively. Reaction of compound 5 with different amines gave the corresponding anilino-derivatives. Compounds 3a, 9a, 10a, 5, and 6b were evaluated for their anticancer activity