ABSTRACT
Hydroflumethiazide [HFM] was ground with different weight ratios of PVP or mannitol. IR spectra and X-ray diffraction patterns of HFM in the prepared mixtures were tested. The ground mixtures were formulated into tablets. The solubility of HFM in distilled water from the formulated tablets was also determined. The results revealed that drug crystals have changed to an amorphous state by the procedure of grinding with either PVP or mannitol. IR showed changes in the drug spectrum after grinding. Tablets containing the ground mixtures exhibited higher dissolution rate compared with those containing the physical mixtures of the components. The drug solubility from tablets containing 20% of either PVP or mannitol [which gave the highest dissolution rate] was 5.78 or 5.10 times the solubility of untreated drug. Accordingly, tablets containing 25 mg HFM can be completely dissolved in about 15 ml of distilled water. This may be useful for immediate production of liquid dosage forms for pediatric and children therapy and for patients suffering from difficulties in swallowing