ABSTRACT
Experimental autoimmune encephalomyelitis [EAE] is a inflammatory demyelinating autoimmune disease of the CNS that servers as an animal model for multiple sclerosis [MS]. Seame oil effect was evaluated in the treatment of EAE in C57BL/6 mice. Seame oil shows profound anti-inflammatory activity and has been traditionally used to treat inflammatory disorders. EAE was induced by immunization of 8 week old mice with MOG[35-55] with complete freunds adjuvant. Therapy with sesame oil was started on day 2 before the immunization. total antioixdant capacity [TAC] was assessed by ferric reducing-antioxidant power [FRAP] method. nitric oxide [NO] producation was also estimated by Griess reaction. After daily intraperitoneal dosage the seame oil significantly reduced the clinical symptoms in c57BL/6 mice with EAE [p< 0.01]. Also, treated mice displayed a significantly delayed disease onset compared with control mice. seame oil significantly increased TAC [p< 0.05], but had no effect on serum nitrie production. Our results suggest for the first time that seame oil therapy may be effective in the prevention of symptomatic EAE. this resistance to encephalomyelities may be associated with inhibition of oxidative stress