ABSTRACT
Diabetes mellitus as a most common metabolic disorder of human has a progressive prevalence that in this disease hyperglycemia from different causes produces several chronic complications in multiple organs by different mechanism. Normoglycemia is the way of prevention of complication that can induce by treatment with oral hypoglycemic agent [O.H.A] or insulin. In type II diabetes the patient treated with O.H.A the failure of treatment is important problem that maybe primary or secondary. Resolving of this problem is changing the treatment to insulin therapy. Before this changing we can add some accessory drug to O.H.A regimen for better controlling of blood sugar. One of these drugs is Chlroquine. In this study we decided to evaluate the effect of Chlroquine on level of blood sugar of DM II. During one year 55 patient in 2 groups as case [25 patients] and control [29 patients] treated with Chlroquine and placebo for 3 months. At first point and end of first, second and third month of study we measured the fasting blood sugar [FBS] and two hours post prandial blood sugar [2hppBS] and evaluate the change of FBS and 2hppBS in each group and between of two groups. The mean age of the case and control group are 53/53 +/- 6/44 and 53/58 +/- 7/83 and mean BMI of two groups are 26/25 +/- 3/6 and 24/95 +/- 3/25. Mean duration of disease of two groups are 7 +/- 4/68 and 6/44 +/- 5/3. Those two groups of patients for these parameters and also for basic FBS and 2hppBS are statistically equal. At the end of three months of study FBS and 2hppBS in each group significantly decreased [P < 0/001]. But this different between two groups are not significant [P-0/661 for FBS and P=0/782 for 2hppBS]. But in the end of the first and second months FBS in case group is significantly lower from control group [P=0/006 for first month and P=0/05 for second one]. Although in other studies that done Chlroquine has reported effective in decreasing of blood sugar of patient with DM type II, but in this study has not approved Reasons of this difference maybe because of different of duration of study or use of hydroxychlroquine instead of Chlroquine or don't being of control group in pervious study