Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome

We studied 60 children affected with idiopathic nephrotic syndrome [INS] plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin [IL]-1beta, IL-6, tumour necrosis factor [TNF] and quantitative urinary beta-2-microglobulin [beta-2-m] excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively [100%] the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively [100%] the control group

Estimation of copper, zinc and magnesium in some renal diseases in children

Serum copper [cu], zinc [zn] and magnesium [Mg] are measured in 30 children suffering from different renal diseases [10 cases with nephritic syndrome [Ns], 10 cases of acute glomerulonephritis [AGN] and 10 cases of chronic renal failure [CRF] as well as in 10 healthy controls, In nephritic patients there was hypocuperemia, hypozincemia and hypomagnesimia. Also there was a correlation between serum Cu and Mg and serum albumin. In patients with AGN, normal serum Cu and Mg was found while here was hypozincemia. In patients with CRF we found hypozincemia, hypercuperemia and hypomagnesmia.Also there was a fair correction between serum Cu and serum creatinie and a negative correlation between serum Zn and serum creatinie