Evaluation of specific biochemical indicators of Helicobactepylori-associated gastric cancer in Egypt

The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer [serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection] in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity [100%]. We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 microg/mL is essential

Synthesis and in vitro anticancer evaluation of some new [tetrahydronaphthalen-2y1] nitrogen heterocycles

Condensation of 2-acetyltetralin I with two aromatic aldehydes afforded the respective chalcones 7a,b. When the reaction of 1 with aldehydes was conducted in presence of ethylcyanoacetate and/or malononitrile and ammonium acetate, it yielded tetrahydronaphthalenyl nicotinonitriles of types 3 and 4. Chalcones 7a,b yielded 2-pyrimidinones 8a,b, 2- thiopyrimidines 9a,b and pyrazoline derivatives 10a,b upon reaction with urea, thiourea and hydrazine, respectively. Reaction of compound 5 with different amines gave the corresponding anilino-derivatives. Compounds 3a, 9a, 10a, 5, and 6b were evaluated for their anticancer activity

Novel 5,6,7,8-Tetrahydronaphth-2-yl heterocycles of possible biological activity

2-cyclocondensation 2 underwent with different alpha-cyanocinnamonitriles to give the corresponding poly substituted pyran derivatives 3[a-d] which upon treatment with carbon disulphide gave the pyranopyrimidindithione derivatives 4[a-c]. Also, treatment of 2 with different aldehydes afforded the corresponding cinnamonitrile derivatives 5[a,b] which upon reaction with 3-methyl-1- phenylpyrazol-5-one gave the corresponding pyranopyrazole derivatives 6[a,b]. Moreover imidazo [2,3-b] thiazoles 8[a,c]; 1,2,3- thia- or 1,2,3- selena-diazoles 10[a,b]; thiazolidinones 16[a,b] and benzoxazin-4-one derivatives 18[a,b] derivatives were synthesized starting with 2-acetyltetralin. Compounds 3[c],11[b],12 were tested as antibilharzial agents and compounds 6[a],8[a] as antileukemia agents in experimental animals. Some of these compounds showed moderate activity