Urea-ammonia toxicity: 2- Some hematological and biochemical investigations on lactulose concentrate treatment

Urea-ammonia toxicities were induced in 3 groups of rumen fistulated sheep. The toxic signs were associated with the pathologically elevated blood ammonia N. The stress of toxicity provokes a significant [P>0.01] increase of P.C.V. percent, haemoglobin contents and blood glucose level. Also there was a significant [P>0.01] increase of the S-AST and S-ALT activities. Both rumen evacuation and lactulose concentrate administration, but not acetic acid treatment, resulted in a decline of the pathologically elevated blood ammonia-N with subsequent improvement of the intoxicated animals. The changed blood constituents returned to more or less normal values and the animals expected to be clinically recovered