Utilization of sulfaguanidine and sulfanilamide as carbon and/or nitrogen sources by certain penicillium species and its inhibition by propyl paraben [nipagin]

The ability of certain penicillii, isolated from sulfaguanidine spoiled tablets to utilize sulfaguanidine and also sulfanilamide has been investigated. Results showed that sulfaguanidine could be utilized as the only carbon source [but not as the only nitrogen source] when the drug replaced sucrose in Czapek's liquid medium. However, in tablet-fillers liquid medium the drug was utilized as both the carbon and nitrogen sources. Sulfanilamide was only utilized when supplied to tablet fillers liquid medium. In an attempt to eliminate biodeterioration of sulfaganidine by the isolated penicillii, nipagin [propyl paraben was found effective. When this antifungal was applied to the drug tablets and also paper discs, fungal growth was inhibited as shown by Czapek's agar plate assay

Biodeterioration of sulfaguanidine in visually spoiled tablets by penicillium species

The work aims to evaluate the potential role of microorganisms in deteriorating sulfaguanidine tablets already found spoiled as shown by their change in colour. Attempts to isolate microbes resulted in the isolation of three Perdcillium isolates. The role of these isolates in utilizing sulfaguaninine and certain other sulfa compounds supplied to Czapek's liquid medium was attempted. Criteria were mycelial dry weight [mg/100 ml culture and mg/gm sucrose consumed], sulfa consumption and sucrose consumption each in mg/100 ml culture. It was found that sulfaguanidine could be utilized by the isolated penicillii when supplied to Czapek's liquid medium, but not sulfanilamide and the sodium salts of sulfadimidine and sulfacetamide. Utilization of sulfa compounds in the literature by fungi has not been recorded. This gives value for the work it this paper

Distribution of certain saprolegnia species in soil and water samples of Nasser's lake

An attempt has been made to study the distribution of Saprolegnia species in soil and water ody of Nasser's lake. Soil and water samples and plant debris we e collected from, different localities for such a purification of these fungi. Results have shown that certain Saprolegnia species were recorded in Nasser's lake, and they were identified as Saprolegnia type 2

occurrence of achlya, dictyuchus and some members of chytrids in soils and water samples of certain Egyptian localities

An attempt has been made to detect the presence of the genera Achlya and Dicryurhus and some members of Chytrids in soils and orate. samples of the Nile and Nasser's lake. Sterile boiled hemp seeds, sterile cellophane paper, sterile skin, sterile house. flies and sterile human hairs were used as baits for such a purpose. Results have shown that Achlya sp., Dictyuchus sp. were recorded in soils and water sample of Nasser's lake, while five types of Chyhrids were recorded in soils : and water samples of the Nile and Nasser's lake