ABSTRACT
Introduction: Glaucoma is a neurodegenerative disease. It is presented by a triad of elevated intraocular pressure [IOP], progressive optic nerve damage, and constriction of the peripheral visual field
Objectives: The aim of this study is to assess the ocular hypotensive effects of some drugs used in treatment of open angle glaucoma [OAG] at Alsaym Ophthalmic Hospital, Wad Medani, Sudan
Methodology: A cross-sectional hospital-based study was conducted at specialized ophthalmological health setting. Patients [n = 200] diagnosed with OAG and treated with different anti-glaucoma drugs were selected randomly to participate in this study. The ocular hypotensive effects of anti-glaucoma drugs were evaluated monthly for 4 successive months, by measuring the diurnal IOP for each patient, using tonometer. The obtained data were collected in especial data collection form and analyzed by IBM SPSS Inc. [IBM SPSS Statistics] Software; Group's Business Analytics Portfolio
Results: Monotherapy of timolol [eye drops 0.5% and 0.1% eye gel], betaxolol 0.5% eye drops produced significant reductions in the total mean of IOP, ranged between 4.4 and 6.1 mmHg, while travoprost 0.004% eye drops showed a remarkable reduction of 7.3 mmHg. Combinations of travoprost with timolol and and/or dorzolamide 2% resulted in significant IOP lowering effects, ranged from 8.9 to 12.7 mmHg. Mono or combined therapy with travoprost was found to be superior to other anti-glaucoma monotherapy
Conclusion: The obtained results showed that travoprost produced clinical significant and superior ocular hypotensive effects when used alone or in combination with timolol and/or dorzolamide. It is thus recommended to use prostaglandin analogues in treatment of OAG because they are the most effective agents in reducing the mean diurnal IOP