ABSTRACT
Sixty cases [50 males and 10 females] affected with fixed drug eruption attending the out patient clinic of dermatology and venereology department of the faculty of Medicine, Alexandria University were examined.Their ages ranged from 21 years to 58 years. Sulphonomides were found to be the commonest drug causing fixed drug eruption [33.33%]. Antibiotics including Tetracycline and ampicillin were next in frequency [23.33%]. Different histopathological changes were encountered. Hydropic degeneration resulting in pigmentary incontinence was the commonest finding [83.33%]. Other findings were in the form of epidermal cell necrosis, oedema of epidermis and upper dermis, dermal cellular infiltration and picture stimulating vasculitis
Subject(s)
Humans , Male , Female , Drug Eruptions/anatomy & histologyABSTRACT
This comparative study included 30 patients to detect the effect of trimethoprim-sulfamethoxazole as compared with oxytetracycline or placebo for treatment of Acne vulgaris. Analysis of the results revealed that both drugs had a beneficial effect on Acne vulgaris and if compared with oxytetracycline, patients on trimethoprim-sulfamethoxazole showed antiseborrheic effect. during therapy
Subject(s)
Trimethoprim , Oxytetracycline , Comparative StudyABSTRACT
Twelve patients with persistent nodular scabies are described. The histology bore a striking resemblance to that of malignant lymphoid neoplasm in ten cases. The possibility of pseudo-lymphomas such as actinic reticuloid and lymphomatoid papulosis must be considered. The reaction could be due to the resorption of toxic material through the epidermis via the intercellular spaces into the dermis