Effects of oral administration of the aqueous extract of the fruit pulp of adansonia digitata on some blood parameters in rats

Adult male Wistar rats were given 400 mg/kg b. wt. daily oral doses of the lyophilized water extract of Adansonia digitata fruit pulp for a period of 4 weeks. The results indicated an increase in total protein, albumin and globulin value [p <0.001] and in SUN [p <0.01] Also, increases were observed in the value of RBC, hemoglobin and MCHC [p <0.01] and lymphocytes [p <0.001], whereas the values of total iron, uric acid, eosinophils, basophils and monocytes counts [p <0.001] were decreased

Clinico-pathological and hematological effects of the administration of the extract of tribulus terrestris on rats

Male Wistar rats were given daily oral doses of an aqueous extract of Tribulus terrestris for a period of 4 weeks. Increased values were observed in total proteins, albumin and gamma-globulins, in addition to an increase in total lipids, alpha and beta- globulin fractions. Also, observed were increased levels in hemogram values, expressed as increased erythrocyte count hemoglobin concentration, MCH and lymphocytes, which are indicative of enhanced erythropoiesis and lymphopoiesis. The results also indicated decreased values of total iron in addition to hypouricemia, decreased MCV, MCHC and an evidence of a selective hypogranulopoiesis. Significant increases were also noted in the weights of the liver, heart and in the total body weight

Studies on the toxic effects of as aqueous extract of Astragalus kahiricusdc orally administered to rats

Adult male Wistar rats were given daily oral doses of an aqueous extract of Astragalus kahiricus for a period of 4 weeks. There was significantly decreased levels of serum enzyme activity of AST, total proteins, inorganic phosphorus, calcium and albumin. Increased levels were noted in the values of glucose, alpha globulins and beta globulins. In the hemogram, there were significant increases in total leucocyte, neutrophil, monocyte and lymphocyte counts. Decreased eosinophil counts, MCHC and MCH values were also recorded. Blood gas analysis showed increased levels of PO2 and O2-saturation and a decreased pH and HCO3 values. Histopathological findings were confined to degenerative and necrotic changes in the liver, islets of Langerhans, kidneys, brain and heart in descending severity. The relative weights of the heart increased and those of the brain decreased

Phytochemical and pharmacological studies on the leaves of ricinus communis L

Phytochemical and pharmacological studies performed on the leaves of Ricinus communis L. revealed; 1. Chromatographic, spectral and analytical studies made on extracts of Ricinus communis L. leaves showed the presence of the neurotoxic alkaloid; ricinine. 2. Toxicity of ricinine appears to be due to the presence of the cyanide group on the molecule. 3. In vitro studies revealed that ricinine is not an inhibitor of cytochrome oxidase, but inhibited the chain of respiratory enzymes in tissue homogenates. 4. LD[50] of ricinine after subcutaneous injection in mice in 10.0 mg/kg b.wt. 5. .Ricinine produces intestinal and uterine stimulation, cardiac inhibition and a hypotensive effect. 6. It reduced renal and coronary blood flow