[Effects of bladder irrigation with chlorhexidine and normal saline on prevention of bacteriuria in patient with foley catheter]

Urinary tract infection [UTI] is the most common infection acquired in both hospitals and nursing homes and is usually associated with catheterization. The aim of this study was to compare the effects chlorhexidine 0.2% with saline for bladder irrigation on preventing bacteriuria in patients with foley catheter. In this randomized clinical trial, 60 neurologic patients 50 years old and over in need of foley catheter for at least 14 days with no UTI at the beginning of the study were enrolled, catheterized by one of the researchers and randomly divided into two groups of chlorhexidine 0.2% and saline. Bladder irrigation was performed on days 3 and 10 following catheterization. A questionnaire and urine analysis as well as culture were used for data collection, each of which was validated and made reliable. Different statistical tests including T-student and Chi square as well as logistic regression were used for data analysis. With respect to negative culture results in both groups on days 1 and 2, a significant difference was found between chlorhexidine [30%] and saline [77.3%] groups [P<0.001]. All subjects contracted infection after 17 days. The relative risk for urinary tract infection in saline group was 2.4 times greater than the other group. During the first 9 days, bladder irrigation with chlorhexidine 0.2% may lead to decreased rate of infection due to catheterization

[Effect of different dosage of intramuscular vitamin D3 on serum 25[OH]D]

Pareneteral vitamin D3 administration, a common practice in Iran, is usually used based mainly on clinical symptoms or serum mineral disturbances. Since studies about the effects and side effects of parenteral vit D3 preparations are limited, this study was designed to evaluate the effect of different intramuscular vitamin D3 dosage on serum 25[OH]D levels. In this study, 54 health volunteers were selected, and randomly assigned to 4 groups, based on their serum vitamin D3. Mean body mass index, age and sex frequency were not significantly different between groups. Mean serum 25[OH]D levels before injections were 27.24 +/- 21.30, 25.21 +/- 17.09, 24.70 +/- 16.8 and 25.10 +/- 14.48 ng/mL in groups I to IV respectively. Vitamin D3 was injected in dosages of 300/000, 600/000, 900/000 units and placebo in groups I-IV respectively. 25[OH]D levels were determined before, and at 2 weeks, 2 months and 4 months after injection. Serum 25[OH]D levels before injection were significantly higher compared to levels assessed 2 and 4 months after injection. At the end of study, in groups I to III, mean serum 25[OH]D levels in group I to IV were 48.20 +/- 28.32 ng/mL, 65.46 +/- 33.52 ng/mL, 72.90 +/- 37.68 ng/mL, and 14.38 +/- 11.14 ng/mL respectively. Frequency of vitamin D hypervitaminosis in groups I, II and III was 9%, 38% and 40% respectively. Usage of parenteral vit D3, especially dosages higher than 300/000 III, is associated with a high risk of vitamin D hypervitaminosis