ABSTRACT
Soft tissue sarcomas of the oral cavity are uncommon malignancies; those of smooth-muscle origin are extremely rare. Leiomyosarcomas of the tongue are very rare. Either surgery or radiation therapy with or without chemotherapy are the treatment modalities which improve prognosis. We are presenting a 32-year-old man with leiomyosarcoma of the lateral aspect of the oral tongue with neck metastasis, who was referred to our radio therapeutic oncology department after glossectomy and radical modified neck dissection. The clinical and pathologic features together with his clinical course will be discussed. Six months after chemoradiotherapy, he developed a single metastasis in his right femur, and then by features of lung metastasis he died in a few weeks, unfortunately