Evaluation of gastric transposition for pharyngeal repair following total laryngopharyngectomy and esophagectomy for hypopharyngeal cancer

This study included 30 patients. To all these cases total laryngopharyngectomy was performed with or without radical neck dissection and the transposed stomach was used for reconstruction at the same sitting with one safe anastomotic line and with or without gastric drainage procedure, i.e. pyloroplasty or pyloromyotomy. After reviewing tacking data the results of this surgical procedure were evaluated, which included all preoperative data, histopathological examination and staging of the tumors; All operative complications; Postoperative complications, morbidity, mortality, entral feeding and endoscopic biopsies; and hospital stay. Comparing of these results with the results of the other surgical procedures which had been used before, such as, Deltopectoral graft, pectoralis major myocutaneous flap, colon interposition and jejunal interposition graft. It was found that the surgical procedure of gastric transposition operation seems evident to be the most adequate procedure for reconstruction of the pharynex after total laryngophorenjectomy for hypopharyngeal carcinoma. The only technical problem in this surgical procedure is whether to perform a gastric drainage procedure or not

Role of female sex hormones on serum electrolytes, fluid volumes, and body weight in normotensive and doca-salt hypertensive female rats

Administration of estrogen to normotensive rats led to significant elevation in plasma and blood volumes and serum sodium; and fall in serum calcium and potassium. Hypertensive rats revealed significant rise in blood and extracellular fluid volumes by estrogen treatment. In normotensive rats, administration of progesterone resulted in non-significant changes in serum electrolytes and body fluid volumes. While significant decrease in blood volume and serum sodium was observed by progesterone treatment in hypertensive group. Combined estrogen-progesterone administration to normotensive rats produced significant increase in plasma, blood, and extracellular volumes and decrease in calcium level. Hypertensive rats-as a result of treatment by combined hormones-revealed significant decrease in plasma and blood volumes, and slight fall in serum sodium level. Progesterone produced significant elevation in body weight of normotensive rats and significantly lowering in body weight of hypertensive rats. Combined estrogen-progesterone administration led to significant decrease in body weight of normotensive and hypertensive rats

Influence of female sex hormones on blood pressure and reactivity in normotensive and doca-salt hypertensive female rats

Administration of estrogen to normotensive and hypertensive rats produced insignificant lowering in blood pressure and heart rate. While progesterone led to insignificant increase in blood pressure of normotensive rats and decrease in blood pressure of hypertensive rats; whereas, heart rate was decreased significantly in hypertensive rats by progesterone. Combined treatment with estrogen-progesterone to normotensive rats induced significant elevation in blood pressure and insignificant change in heart rate. Hypertensive rats revealed insignificant rise and decrease in blood pressure and heart rate, respectively by combined hormones. Infusion of 600 ng/l00 g norepinephrine to normotensive rats pretreated with estrogen induced significant fall in systolic blood pressure. Histological examination of aorta exhibited that estrogen or progesterone administration to normotensive rats revealed slight decrease in collagen and elastic fibres. While untreated hypertensive, hypertensive treated with estrogen or progesterone, and normotensive treated with combined estrogen-progesterone revealed increase in the wall thickness and few elastic fibres in the media. Also hypertensive rats treated by estrogen- progesterone exhibited marked increase in the wall thickness and decrease in elastic fibres