Pharmacological study of aqueous extract of Scoparia dulcis L. on gastrointestinal tract

The research study was conducted in an attempt to analyze the relative pharmacological effect of the aqueous extracts of Scoparia dulcis L. on the gastrointestinal tract. The Gastrointestinal Motility [GI-Motility] test, Castor oil and MgS0[4] induced diarrhoeal tests were performed utilizing laboratory mice. Scoparia dulcis L. showed laxative effect as revealed by the GI-Motility test, the Castor oil induced and MgSO[4] induced diarrhoeal tests

Pharmacological study of Rasaraja Ras an Ayurvedic metal Preparation

Pharmacological effect of the drug Rasaraja Ras [RRR] was studied using albino mice. RRR reduced both spontaneous motor activity and, amphetamine induced hyperactivity. Conclusion from open field test, hole cross test, hole board test and climbing out test suggest a CNS depressant activity. But RRR did not potentiate pentobarbital sleeping time and it did not show any neurotoxicity or marked ataxia at this dose level. RRR exhibited analgesic activity and it lowered both the normal rectal temperature and pectin induced hyperthermia. On 24-hour metabolic studies RRR revealed reduction in food and water intake and also in defaecation. In 30-day growth study a dose dependent reduction in body weight gain was revealed

Effect of aqueous extract of Ocimum sanctum Linn. [Labiateae] on gastrointestinal tract

The effect of O. sanctum L. on gastrointestinal [GI] motility by BaSO4 revealed that O. sanctum L. aqueous extract significantly increased the peristaltic movement of GI tract compared to control. But the in vitro result on isolated guinea pig ileum differs from the in vivo gastrointestinal motility result. The in vitro result of hot water extract showed a dose dependent increase in relaxation on isolated guinea pig ileum similar to previous findings and it showed no interaction with acetylcholine

Bioactivity studies of the aqueous extract of Ocimum sanctum linn. [Labiateae]

Hot water extract of Ocimum sanctum L. [Labiateae] showed bioactivity against brine shrimp lethality bioassay. The LC50 value was found l35micro g/ml and the ED50 value was calculated l3.5micro g/ml. The extract was ineffective on wheat rootlet growth inhibition bioassay. O. sanctum showed dose related antimicrobial activity against some clinical bacterial isolates Escherichia coli, Staphylococcus aureus and Salmonella typhi but failed to exhibit activity against Pseudomonas aeruginosa and Klebsiella pneumoniae

Asokarishta-Studies on Metabolism and Gastro-intestinal Motility

The 24 hours acute metabolic study revealed certain striking aspect of the pharmacological profile of Ascokarishta and Saraca asoca [Roxb]. Asokarishta causes no change in food intake but decreases the defecation rate and with low water intake maintains normal rate of excretion. But Saraca asoca [Roxb] causes no change in food intake and defecation followed by slight decrease in water intake but no difference on urinary output. The gastro-intestinal motility test revealed that Asokarishta did not change the motility at all, but Saraca asoca [Roxb] slightly increased the motility whereas the rest of the components lowered the motility. In 30 days chronic administration study all of the components slightly decreased the rate of gain in body weight compared to control

Effects of the crude extracts of Nigella sativa linn on isolated guinea-pig tracheal chain preparations

The aqueous extract of the seeds of Nigella sativa Linn. cause spontaneous relaxation on isolated tracheal chain preparations. The extract does not interact with the acetylcholine, but it inhibits the contractile actions of histamine on isolated tracheal chains. All the effects of N. sativa on isolated tracheal tissue preparations are found to be dose dependent

Acute and chronic metabolic study of nigella stavia linn

In the acute metabolic studies using mice as experimental animals KSJ showed an increase in food intake but almost no change to slight decrease in defaecation. Interestingly though there was no change in water intake but there was a large increase in the amount of urinations. Though the month-long body weight gain study was not uniform in choosing initial weight of the experimental animals but it can be safety concluded that KSJ causes a decrease in body weight gain in rats of both the sexes. Male rats showed more variation in their gaining of body weight. In the organ-weight studies, there was an increase in weight of liver only in the female rats. The weight of kidney increased irrespective of the sex of the rat. Adrenal weight increased only in the male rats. Among the male gonads there was an increase in weight in cauda epididymides and seminal vesicles. Gross histopathological changes were noticed in the kidney and testes. Possible histopthological changes were noticed in the liver and small intestine. Abnormal changes were noted in the pancreas, stomach, glomeruli, urinary bladder, testes, adrenal cortex, adrenal medulla and lachrymal gland

Clinical trials on male normotensive subjects and female uti patients treated with the seeds of nigella sativa linn

In the clinical trial to study the effects of KSJ on blood pressure it was noted that KSJ depressed both the systolic and the diastolic blood pressure starting from 1 hour till end of 5 hours after the oral intake of KSJ. But the diastolic pressure was significantly low only from 2 hours after the oral intake of KSJ. All the results of systolic and diastolic pressure are statistically highly significant. In the clinical trail with female UTI patients there was a decrease in pus cells in the urine after the patients were treated with KSJ in comparison to their pre-drug urine examination report