Steady state behaviour of the ascending limb of Henle's loop in a nephron below the juxta-medullary apparatus

The nature of many kidney diseases is still unknown and so the therapy. The reasons for such uncertainty are numerous but, the most important is the great difficulty to study events successfully in the cellular level and the inaccurate results for experiments obtained at such level. So many of the phenomena which cause disease are still unknown and subsequently they are the subject of many contradicting theories. The strong tools of modeling is now adapted to predict concentration profile along the ascending limb of Henle. The reason for such a choice lies in its difference from that of the descending limbs as being performing active transport and satisfying requirements of modeling. It is greatly similar to plug flow reactor in nature