ABSTRACT
The effect of flunixin meglumine [FM] in doses of 4 and 8 mg/kg b. wt. on reproduction in rats were studied. The tested doses were given daily intramuscularly to male rats for 65 days. Sex organs weights, anal semen picture, testosterone, FSH and LH hormone levels as well as mating performance were the criteria used to evaluate the reproductive efficiency of treated rats. Prolonged i.m. administration of FM for 65 days to male rats, significantly decreased the weights of most genital organs, sperm cell concentration, sperm motility and live sperm% associated with an increase in the percentages of dead and morphological abnormal spermatozoa of treated rats. A decrease in plasma testosterone level and increase in plasma LH and FSH levels was observed in the treated groups. Administration of the tested drug to male rats decreased their ability to mate females. Moreover, the number of viable feti in some pregnant rats was significantly decreased as compared with that of controls
Subject(s)
Fertility/drug effectsABSTRACT
The prothrombin time, activated partial thromboplastin time, fibrinogen concentration and platelet count were determined in diabetic and insulin treated diabetic mature male albino rats. The values of prothrombin and activated partial thromboplastin time showed significant [p <0.01] decrease in the diabetic and semidiabetic rats at 10 and 20 days following treatment, fibrinogen concentration increased in diabetic rats, 10 and 20 days post-insulin administration and in the semidiabetic rats after 20 days. Platelet count increased significantly in the diabetic rats treated with 40 U insulin daily after 20 days although the clotting parameters were not affected. The results presented are indicative of coagulation activation in diabetic rats and the periodic administration of insulin will reverse the adverse effects of diabetes
Subject(s)
Animals, Laboratory , Male , Diabetes Mellitus, Experimental/prevention & control , Insulin/bloodABSTRACT
The prothrombin time, activated partial thromboplastin time, fibrinogen concentration and platelet count were determined in diabetic and insulin treated diabetic mature male albino rats. The values of prothrombin and activated partial thromboplastin time showed significant decrease in the diabetic and semi-diabetic rats at 10 and 20 days following treatment. Fibrinogen concentration increased in diabetic rats, 10 and 20 days post-insulin administration and in the semi-diabetic rats after 20 days. Platelet count increased significantly in the diabetic rats treated with 4 U insulin daily after 20 days, although the clotting parameters were not affected. The results presented are indicative of coagulation activation in diabetic rats, and the periodic administration of insulin will reverse the adverse effects of diabetes