Association of the estrogen receptor gene with oral health-related quality of life in patients with dentofacial deformities

Abstract This study aimed to evaluate the associations between oral health-related quality of life (OHRQoL) and patient-associated factors and polymorphisms in the estrogen receptor 1 (ESR1) and 2 (ESR2) genes in patients with dentofacial deformities (DFD). This cross-sectional study included 234 adult individuals. Data such as age, sex, and the type of facial profile (I, II, or III), were collected, and the short-form oral health impact profile 14 (OHIP-14) questionnaire was used to assess their OHRQoL. DNA was collected from oral mucosa cells, and the polymorphisms in ESR1 (rs2234693 and rs9340799) and ESR2 (rs1256049 and rs4986938) were evaluated using real-time polymerase chain reaction. The data were subjected to statistical analysis at a significance level of 5%. Individuals over 28 years of age exhibited worse OHRQoL (p = 0.003) than individuals aged less than or equal to 28 years. Women had worse OHRQoL than men (p < 0.001). Profile II individuals had worse OHRQoL in the social disability domain than profile III individuals (p = 0.030). Genetic analysis showed that rs9340799 was associated with OHRQoL in the functional limitation domain, and GG individuals exhibited worse OHRQoL than individuals carrying the AA/AG genotypes (p < 0.030). In the social handicap domain, individuals with GG genotype in rs9340799 exhibited worse OHRQoL than AG individuals (p < 0.043). Collectively, our results reveal that factors including age, sex, and type of facial profile, are associated with OHRQoL in patients with DFD. In addition, individuals with the GG genotype in rs9340799 (ESR1) may experience a negative impact on OHRQoL in the functional limitation and social handicap domains.

Redistribuiçao da pele, gordura e sistema músculo-aponeurótico nas ritidoplastias / Skin, fat and muscle aponeurosis rearangement for rhytidoplasty

A plicatura em leque do plastima tem como objetivo manter o equilíbrio estético entre a face e a regiao cervical. Por ser realizada diretamente sobre a alteraçao existente, torna-se mais eficiente para a correçao da deformidade. Garante melhor definiçao para o contorno mandibular, bem como, para a correçao da deformidade. Garante melhor definiçao para o contorno mandibular, bem como, para o ângulo submentocervical. Da mesma forma, realiza a suspensao da comissura oral e sulco nasogeniano, harmonizando o contorno facial. Sua associaçao com a lipoaspiraçao submentonina e submandibular favorece a acomodaçao da pele sobre o novo arcabouço muscular, com grande melhoria para o perfil cervical

Avaliaçäo do crescimento do lábio, após a sutura entrecruzada do músculo orbiculares oris, nas fissuras labiais unilaterais / Growth evaluation of the repaired unilateral cleft lip through the double-breasted approach for the orbicularis oris muscle

A sutura entrecruzada do músculo orbicular do lábio permite a reparaçäo anatômia e funcional do lábio, através do realinhamento das suas fibras ao nível da fissura. A restauraçäo do paralelismo das fibras musculares, bem como, a tensäo muscular criada, tornaram possível o crescimento equilibrado do lábio. Volume muscular criado por este tipo de sutura preenche a deficiência óssea ao nível da fissura. Os retalhos cutâneos fornecem alongamento adicional para o lábio e a sutura em "W" da mucosa evita retraçäo secundária do lábio