Phenotypic and genotypic profile in Egyptian non-Hodgkin's lymphoma

All the cases of well differentiated lymphocytic neoplasm showed double arrangement along IgH and TCR "beta" genes. These immunogenetic data suggested that B cell well differentiated lymphocytic neoplasms are relatively homogeneous disorder. This double rearrangement was found to be 100% in grade I, 20% in grade II and 22% in grade III. This decrease in the frequency of double rearrangement along the line of differentiation may support the view point that small cell NHL arise from immature group and as the cell differentiates, commitment to the corresponding cell line is more and more achieved

Clinicopathological study of chronic myelogenous leukemia in Egyptian patients

The clinicopathological features of 133 patients with chronic myelogenous leukemia [CML] presented to the National Cancer Institute, Cairo during the year period 1983-1986 were studied. The mean age was 40 years [7 months to 73 years], with a slight male predominance [M:F ratio of 1.18:1]. Early fatigue was the commonest symptom, and splenomegaly was present in 97% of cases. Haematological findings were leucocytosis [100-300 x 103/mm3] in more than 50% cases in the chronic phase, anemia [Hb <10 g/dl in 60% of patients]. Twelve patients were in the accelerated phase and 14 others were in the blastic phase. Myelofibrosis was seen in 5 patients only. The median survival of patients in the chronic phase was 24 months and 4 only for the metamorphosis patients