ABSTRACT
Aim:This study aimed to compare between the effect ofpharmacoinvasive strategy (PI)& primary percutaneous coronary intervention (P-PCI) according to PCIrelated delay (door to ballon) on the mortality and morbidityduring in-hospital stay and after 30-day follow up. Moreover, leftventricular systolic function was assessed by two-dimensional echocardiography at cardiology department, Tanta University. Patients and Methods:The study was conducted on 300 patients that were dividedinto 2 main groups. Group A consisted of patients had primaryPCI as reperfusion therapy and further divided into threegroups according to PCI related delay (door toballon). Group A1, PCI-related delay is ≤60 minute(92patients). Group A2, PCI-related delay is >60 to ≤ 90 minute. (54patients). Group A3, PCI-related delay is >90minute (78 patients). The second group (group B), include patients who undergopharmaco-invasive strategy, PCI within 24 hour afterthrombolysis (76 patients). the second group, coronary angiography was done immediately in cases of failedthrombolysis and for successful thrombolysis; coronaryangiography was performed within 3 –24 hours. Results:During hospital stay, more patients in group A3 died than those of group B orgroup A1, A2 with no statistical significance.In addition, morepatients in group A3 showed heart failure symptoms withstatistical significance than those of group B, A1 and A2. Bleeding complications occurred significantly moreingroupB. Duringfollowupvisits more patients in group A3 complained ofheart failure symptoms with statistical significance than those of group B, A1, A2 patients. Conclusion:Primary PCIwithout door to balloon time delay (≤90 minutes)was encouraged and hadthebest results on morbidity and mortality. Also, pharmacoinvasive strategy was encouraged as being better than primary PCIwhen door to balloon time showed marked delay( <90 minutes)
ABSTRACT
Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active drugs. To solve this paradox, we need objective airway biomarkers to tailor the proper medications to the proper patient. Biomarkers should have one or more of the following characteristics: 1] could differentiate poor symptoms perceivers from over-perceivers, 2] could predict disease activity and hence disease outcome, 3] could clarify asthma phenotype responders from non-responders, and finally 4] could characterize different clinical asthma phenotypes. Therefore, we have conducted a review of literature trying to apply those four parameters to different airway inflammatory biomarkers. We found that FeNO fulfilled the four proposed clinical parameters of airway inflammatory biomarkers whereas; serum periostin was the single best systemic biomarker of airway luminal and tissue eosinophilia in severe uncontrolled TH2 asthma phenotype. Thus, this may be considered a trial towards tailoring the proper medication to the proper patient. However, application of biomarkers in clinical practice requires easier and cheaper techniques together with standardized methods for sample collection and analysis
ABSTRACT
Due to widespread of human exposure to electromagnetic fields, there has been increasing public concern about the potential health risks from low-frequency electromagnetic fields; ELF-EMF. The magnetic fields [MFs] affects functions of the living organisms, such as DNA synthesis and ion transportation through the cell membranes. In the present work, the effects of short-term exposure to magnetic fields [MFs] prior to incubation were investigated on the ancliaysical blood properties of chicks hatched from layer-type breeder eggs. The eggs were exposed to a MF of 0.75mT at 50 Hz for 20, 40 and 60min before incubation. This study was performed by measuring the dielectric relaxation of hemoglobin [Hb] molecules and the membrane solubility of red blood cells [RBCs] using the non-ionic detergent octylglucoside. Exposure of the eggs to a MF increased the conductivity of the Hb molecules. The pronounced increase is the conductivity of the exposed eggs might be attributed to an increase in the surface charge of the Hb macromolecules, resulted from the formation of highly active molecular species. This speculation can be supported link increase in the relaxation time of the exposed groups. The solubilization process of the RBC membrane indicates a lass in the mobility of RBCs in the blood of hatching chicks
ABSTRACT
Objective: To study the relation between serum level of Aflatoxin B1 [AFB1] and Hepatitis C Virus [HCV] infection with or without complications, i.e., cirrhosis and Hepatoceiiuiar Carcinoma [HCC]
Subjects and Methods: A cross-sectional comparative study inctuded 270 tients attending the University of Alexandria Student Hospital, divided into two groups: first group [n=135] HCV seropositive with raised liver enzymes [ALT and AST], 58 ot them are proved to be cirrhotic by ultra-sound, 14 of them suffer HCC. Comparative second group [n=135] are HCV seronegative, randomly chosen and matched with the other group. Both groups were questioned, clinically examined and serum level of AFB1 was measured using the indirect ELISA technique
Results: Mean serum level of AFB1 among HCV cases was significantly much higher than controls [358.1+/-394.6 ng/ml] vs. [129.5+/-169.3 ng/ml], p=0.000. Mean serum level of AFBt was higher in cases suffer HCC than cirrhotic patients and than HCV non-cirrhotic patients [618.1+/-667.7 , 460.4+/-486.0 and 281.0+/-288.7 ng/ml, respectively. There was no relation between serum level of AFB1 and Sex, age, residence, socioeconomic level, and liver enzymes level in both groups
Conclusion: HCV infected individuals are facing a great risk to devetop long term hepatic complications especially HCC, AFB1 exposure as a known carcinogen is an additional risk. Strict national measures against Atlatoxin contamination of tood are to be considered in countries with high prevalence of hepatic virus C and B as well
ABSTRACT
The aim of this study was to measure the serum level of magnesium in insulin-dependent diabetic patients and the effect of magnesium depletion on the conduction velocity in the peripheral nerves of the lower limbs. This study was conducted on 45 subjects divided into 3 groups: Group Ia: 15 diabetic subjects [type I] with serum Mg level /= 1.7mEq/L. Group II: 15 healthy control subjects. All subjects were studied by proper history and clinical examination, routine laboratory investigations, HbAlc, serum magnesium level and nerve conduction study of common peroneal, posterior tibial, and sural nerves. Our findings showed decrease serum magnesium levels in diabetic groups than in control group [F= 67.823, P= 0.000], and those subjects with hypomagnesemia showed a significant decrease in motor nerves conduction velocity; common peroneal, and posterior tibial nerves [F= 17.954, 31.452, and P= 0.000] as well as a significant decrease in sensory nerve conduction velocity; sural nerve [F= 19.889, P= 0.000]. Significant negative correlations were found between fasting and post prandial plasma glucose, HbA1c, and serum magnesium level [P= 0.000]. Significant positive correlations were found between serum magnesium level and nerve conduction velocity [motor and sensory]. Hypomagnesemia in type-1 diabetes mellitus may be responsible about bad control of diabetes as well as occurrence of complications, especially neuropathy. Motor and sensory nerves conduction velocity decreased significantly and positively correlated with serum micro g level. Mg supplementation in large doses may improve nerve conduction
Subject(s)
Humans , Male , Female , Magnesium/blood , Magnesium Deficiency , Neural Conduction , Glycated Hemoglobin , Body Mass Index , Diabetic Neuropathies , Diabetic RetinopathyABSTRACT
To evaluate the effects of single rod augmented with sublaminar wiring in correcting scoliosis. Special attention was. 25 adolescent patients with mean age of 12.9 years. These included 9 boys and 16 girls. All cases were examined clinically and radiologically before and after surgery. Surgery in all cases included the use of single rod fixed with transpedicular screws [except one case where kooks were used in the upper part of the curve]. Sublaminar wires were used to supplement the fixation. Moreover at the sites intended for screw fixation these openings were extended a bit laterally to facilitate screw fixation. The mean thoracic curve preoperatively was: 54.7 degrees, while that of the lumber was 37.3 degrees. Flexibility of the thoracic curve had a mean of 48.1% while that of the lumbar was 46.7%. The mean number of vertebrae included was 10.7 vertebrae. The mean number of screws was 5.1 screws and a mean of 4.4 sublaminar wires was used. The mean correction of thoracic curve was 59.9% that of lumbar was 55.5%. The factors that was significantly affecting the correction were the flexibility of the thoracic curves, the number of vertebrae included in instrumentation, number of screws used. The number of sublaminar wires used were positively but insignificantly correlated to the degree of correction
Subject(s)
Humans , Male , Female , Adolescent , Bone Wires , Bone Screws , Spinal Curvatures , Magnetic Resonance Imaging , Follow-Up StudiesABSTRACT
In this study, 51362 children [26538 males and 24824 females] were selected by systemic random sampling representing 4% from the total number of children in both primary schools [group I = 33297 children] and preparatory schools [group II = 18065 children] in Cairo. They were subjected to auscultation which revealed MVP criteria in only 221 children; 100 children in group I and 121 children in group II with a high statistical significant difference. Those 221 children were subjected to EGG, CXR and color/Doppler echocardiographic examination. It was found that only 120 children have MVP, 52 children from group I and 68 children from group II with a high statistical significant difference