ABSTRACT
In Jordan, Salvia dominica L. is widely distributed while Salvia hormium L. is scarcely found. The objective of this study was to determine the volatile oil composition of the fresh and dried aerial parts of these two species, collected during flowering time. The hydrodistilled volatile oils were analyzed by gas chromatography-mass spectrometry [GC/MS]. The volatile oil of fresh and dry S. dominica was composed mainly of oxygenated monoterpenes [79.0% and 68.1%, respectively]. The major components detected in the oils of fresh and dry S. dominica L. were linalool [31.4% and 18.3%, respectively] and alpha terpineol [25.4% and 15%, respectively]. Mono- and sesquiterpenoids were detected in the volatile oils of fresh and dry S. hormium in nearly equal amounts. Alpha cadinene [7.8% and 11.4%, respectively] was the predominant constituent in oils obtained from fresh and dry plants. Eugenol [7.3%] was found only in the volatile oil of fresh S. hormium
ABSTRACT
To evaluate the benefit of adjuvant 5-fluorouracil-based chemotherapy in .patients with Dukes' B2 colon cancer, using event-free survival [EFS] and overall survival [OS] as primary end points. Patients and Methods: One hundred patients with Dukes' B2 colon cancer, attending the outpatient clinics of Clinical Oncology and Nuclear Medicine Department, Mansoura University Hospitals, during the period from January 1998 to December 2002, were reviewed retrospectively for comparing patients who received adjuvant chemotherapy following radical surgery and those who were under follow-up. With a median follow-up of 79.5 months, the 5-year EFS and OS in the adjuvant chemotherapy arm were 101.6 and 103.3 months respectively, compared to 94.8 and 99.3 months in the control arm respectively, both were statistically insignificant. Our study does not support the routine use of adjuvant 5-fluorouracil plus leucovorin chemotherapy in all patients with Dukes' B2 colon cancer, as true benefit
Subject(s)
Humans , Male , Female , Chemotherapy, Adjuvant , Fluorouracil , Follow-Up Studies , Survival Rate , PrognosisABSTRACT
Forty male albino rats were used to study the histological picture of testis at different age groups. They were classified into three groups; prepubertal [20 rats divided equally into two subgroups: A [7 days], and B [21 days]], adult [10 rats, 3-4 months] and senile [10 rats, 16-18 months]. After anesthesia, small pieces of testes were dissected and processed for light and electron microscope study. In rats aged 7 days, the testis showed seminiferous cords lined by spermatogonia and Sertoli cells. Large rounded, pale-stained gonocytes occupied their centers. The cords were surrounded by more than one layer of myoid cells. Leydig cells were small and found in clusters. Their cytoplasm showed many lipid droplets and mitochondria with disrupted cristae. At 21 days of postnatal life, most cords turned into tubules lined by spermatogonia, spermatocytes and Sertoli cells, whereas, apoptotic gonocytes appeared towards the adluminal side. Tight junctions began to appear on cell membrane of Sertoli cells. In the adult group, the seminiferous tubules were lined by stratified germinal epithelium with spermatids at different stages of development and surrounded by a single layer of flattened myoid cells. Inter-Sertoli tight junctions divided the tubules into basal and adluminal compartments. Leydig cells had oval nuclei and their cytoplasm showed sER. mitochondria, few lipid droplets of variable sizes. In old aged rats, there were wide interstitial spaces. Some tubules showed wide lumina and reduced epithelial lining. They were surrounded by thickened irregular basement membrane. Germ cells of such tubules showed pyknotic nuclei and wide intercellular spaces. Sperms had highly attenuated darkly stained head, and malformed tail. Sertoli cells showed large lysosomes and vacuoles. Leydig cells appeared with irregular nuclei and their cytoplasm showed many lipid droplets and vacuoles. It could be concluded that the two extremities of age have adverse effects on fertility in males. Giving birth at senility for good generations is in doubt