Further studies an antoclaved cercarial vaccine against Schistosomasis: Safety, longevity and stability

This study was performed to adjust the dose and to assess vaccine safety, longevity and stability as well as the possibility of transplacental transmission of immune response from pregnant mice to their offspring. The results showed that two doses of the lowest most effective concentration of autoclaved cercarial vaccine [ACV] that achieved the high percentage reduction of worm burden were safe as demonstrated by the absence of any local or systemic side effects, normal blood picture and normal liver and kidney function tests. ACV is stable when kept either at 4C for 6 months or at-35C for up to 12 months and it offers a considerable duration of longevity. The offspring of vaccinated mothers did not show any signs of protection against challenge infection

Coagglutination [Co- A]: a rapid test for the diagnosis of expenimental Trichinellosis

This work aimed to evaluate Co-A test as a new diagnostic tool in the detection of T. Spiralis antigens in both sera and urine of experimentally infected mice as compared with ELISA for the diagnosis of trichinellosis. The results obtained by Co-A test were closely correlated with those of ELISA. The results showed that both tests were capable to detect T. spiralis antigen in the urine of lightly-and heavily-infected mice only at the 30th day post infection. So, Co-A is an accurate, easy and rapid test that can be used on large scales for the diagnosis of trichinellosis