ABSTRACT
Anticoagulant response to activated protein C [APC] was studied in 15 healthy subjects and 35 patients with type 2 diabetes mellitus using a modified activated thromboplastin time assay. The results were expressed in terms of the APC sensitivity ratio [APC-SR]. In addition, plasma levels of protein C, protein S and AT III were measured. APC-SR was significantly higher in diabetic patients compared to controls. AT III was significantly lower in diabetic patients compared to controls. No significant differences were observed between patients and controls as regards protein C activity and free protein S levels. In conclusion, the data suggested a role for AT III and APC cofactor activities in the regulation of the anticoagulant response in type 2 diabetic patients. The enhanced anticoagulant response to APC as well as up-regulation of the protein C/protein S system may be effective in controlling hemostatic balance type 2 diabetes