ABSTRACT
In traditional Chinese medicine, ganoderma lucidum are widely used as medicine for a variety of diseases, such as chronic bronchitis inflammation, hyperlipidemia, hypertension, neurasthenia, hepatitis, leukopenia, and adjuvant treatment of cancer. The aim of this study was to evaluate its effect against cisplatin-induced nephrotoxicity in adult male albino rats. Forty five animals were classified into 5 groups 9 rats for each group. Group [1] fed on basal diet [negative group]; groups [2-5] were injection with cisplatin [5mg/kg body wt.] Intraperitoneally to induce nephrotoxicity in rats; group [2] fed on the basal diet as positive control group [+ve]; remained groups fed on the basal diet and supplemented with ganoderma lucidum at 5,10 and 15 g/kg diet, respectively. Results revealed that positive control group had significant increase in serum levels of creatinine, urea, uric acid, urea nitrogen and total protein as well as Malondialdehyde [MOD] but had significant decrease in serum levels of superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPX] and glutathione [GSH] as compared to the negative control groups. While supplemented with different levels of ganoderma lucidum caused significant decreased in serum levels of creatinine, urea, uric acid, urea nitrogen and total protein as well as [MOD]. But had significant increased in serum levels of [SOD],[CAT],[GPX] and [GSH] as compared to the positive control group. From the present results it can be concluded that ganoderma lucidum feeding possess a therapeutic effect against cisplatin that induced nephrotoxicity in rats and inhibit oxidative stress. According to above results the consumption of ganoderma lucidum can be used to treat nephrotoxicity