ABSTRACT
Langerhans cell histiocytosis (LCH) is a rare proliferative histiocytic disorder of unknown etiopathogenesis. The clinical presentations range from unifocal or multifocal bony lesions to disseminated form of the disease with multiorgan involvement. The unifocal bony lesion (Solitary eosinophilic granuloma) carries a good prognosis. We report such a case of unifocal bony lesion of LCH involving tibia in a 8 years old female child. The clinical and radiological manifestations were non specific, enlightening the suspicion of osteomyelitis. A curettage excision biopsy was performed which on microscopy revealed sheets of eosinophils in milieu of Langerhans cells, giant cells, lymphocytes and plasma cells. Langerhans cells showed strong immunoreactivity for S-100 and CD1a antigen thus establishing the diagnosis of LCH. LCH of long bones may be a rare entity but it must be kept in mind as a differential diagnosis whenever a child presents with features of osteomyelitis.
ABSTRACT
Clinical microbiological and histopathological confirmation plays a key role in the diagnosis of tuberculosis. The present study correlates Zeihl Nelson staining , Lowenstein Jensen culture media, Montoux test and histopathology in the diagnostic yield of extrapulmonary tuberculosis.Result of current study shows out of total 255 samples, 24 (9.4 %.) showed the presence of mycobacteria by either of the following methods: LJ culture media, ZN staining, histopathology and montoux test.
ABSTRACT
Background: Fine needle aspiration cytology (FNAC) is widely considered as the diagnostic technique of choice in the assessment of thyroid lesions. Aims: The aim of this study is to determine the utility and diagnostic accuracy of FNAC of thyroid lesions performed at our institution and to compare our experience with that of the experts from other regions of the world. Setting and Design: The present study is a five-year retrospective study of FNAC of thyroid lesions performed in the Pathology Department of our institute, during the period January 2004 to December 2008. The FNAC findings were correlated with the histopathological diagnosis, wherever available. Materials And Methods: 0 The records of 252 patients who had undergone FNAC during the study period were retrieved and information about age, sex, FNAC, and Histopathological diagnoses were extracted and the corresponding original slides were reviewed. The cytological results were classified as inadequate, benign, suspicious, and malignant. The histopathology diagnosis was classified as non-neoplastic (benign) and neoplastic (malignant). Results: A total of 252 FNACs of thyroid lesions were done during the study period. The results of the FNA cytological diagnosis showed that four (1.6%) of the patients had FNAs, which were inadequate for cytological assessment, 228 (90.5%) patients had benign lesions, 17 (6.7%) had lesions that were suspicious for malignancy, and three (1.2%) had malignant neoplasms. The correlation of the FNAC findings with the histopathological diagnosis, showed that our FNAC diagnostic accuracy rate was 96.2%, with a sensitivity of 66%, and specificity of 100%. Conclusions: The results of our study are comparable with the current published data and demonstrate that FNA cytology is a sensitive, specific and accurate initial diagnostic test for the preoperative evaluation of patients with thyroid swellings in our setting as well. The clinicians should be encouraged to embrace this procedure in the initial management of such patients.
Subject(s)
Adolescent , Adult , Aged , Biopsy, Fine-Needle , Child , Cytodiagnosis , Female , Humans , Male , Middle Aged , Retrospective Studies , Sensitivity and Specificity , Thyroid Nodule/diagnosis , Thyroid Nodule/surgery , Young AdultABSTRACT
Primary squamous cell carcinoma of endometrium is a rare entity. Only 64 cases have been documented in the literature. We report a case of 60-year-old postmenopausal woman who presented with abdominal distention and blood-stained vaginal discharge for 6-7 months. Clinically, chronic pyometra was considered. Total abdominal hysterectomy was performed and histopathologically, it was diagnosed as a case of primary squamous cell carcinoma of endometrium with extensive squamous metaplasia and dysplasia.