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1.
Article | IMSEAR | ID: sea-188550

ABSTRACT

Background: Platelet Transfusion are used for the treatment and prevention of bleeding in patients with decreased number and function of platelets. Platelet for transfusion can be provided by platelet concentrates, which are obtained either by PRP or buffy coat method from whole blood or by apheresis. Platelet Recovery in a patient is influenced by the transfused dose of platelets which in turn is dependent on the platelet yield. Aim of Study: In this study, our main objective is to identify the donor parameters that influence the platelet yield obtained by apheresis.Methods: This prospective study was undertaken in the Department of IHBT.140 healthy donors were selected for plateletpheresis according to guidelines laid down by Drugs and cosmetics Act over a period of one year. The plateletpheresis procedures were performed on Haemonetics MCS plus separator. Yield predicting donor variables included in the study were Age, Gender, Haemoglobin concentration, Haematocrit and Platelet count. The relationship between predonation donor variable and yield was studied using pearson correlation. Results: The Mean platelet yield was 3.19±0.48×1011per unit. Mean predonation platelet count of donor was 2.77± 0.46×105/μl. Mean age of the Donor was 30.31±8.14. Positive Correlation was observed between platelet yield and predonation platelet count of donor(r=0.318, P value 0.0001) which is significant. No such correlation was seen between platelet yield and Haemoglobin(r=0.131, P value 0.122), Haematocrit (r=0.058, P value 0.499), Age of Donor(r=0.034, P value 0.692). Conclusion: The possibility of obtaining higher platelet yield reduces the frequency of platelet transfusion and number of donor exposures with important consequent clinical and economic advantages.

2.
Article in English | IMSEAR | ID: sea-175115

ABSTRACT

Background: Hepatitis E Virus (HEV) infection occurs predominantly by the faeco oral route. Cases of transmission through blood transfusion have also been reported. Currently, blood donors in India are not screened for HEV. So the present study has been undertaken to know the sero-prevalence of HEV and to determine the status of endemicity of this infection. The aim of this study is to determine the sero-prevalence of hepatitis E virus (HEV) among blood donors in a tertiary care teaching hospital. Method: 551 blood donors’ samples analysed for presence of Anti HEV IgG using 3rd generation HEV ELISA kit. The serum samples were also tested for detection of HIV, HBsAg, HCV infections, Syphilis and Malaria. Results: The study included 551 donors, of which 99% (546) were males. The sero-positivity for anti-HEV IgG antibodies was 10.7%, the maximum sero-positivity being in the age group 51-65. All the donors were non- reactive for HIV, HCV, HBsAg infections, Syphilis and Malaria. Conclusion: High Prevalence of IgG antibodies (10.7%) shows that HEV is endemic in our region. However, more studies with confirmatory assays need to be done before making it a mandatory screening test for blood donors.

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