ABSTRACT
Background: Acute Myocardial Infarction [AMI] is the leading cause of disability and death in Iran and many other countries
Objective: To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia
Methods: In this cohort study we recruited and followed 50 patients with acute anterior myocardial infarction [AAMI] for developing cardiovascular accidents in a 6-month period. CCL5 and CCL18 levels were measured on admission, at day 5 and at day 180 posthospitalization
Results: CCL18 and CCL5 levels at day 180 were higher in patients with late [day 180] and early [day 5] LVEF less than 35% compared to those with higher LVEF [p=0.05 and p=0.042, respectively]. There was a negative correlation between early and late LVEF and regional wall motion abnormalities [p=0.001 and p=0.002, respectively]. There was also a trend of negative correlation between CCL18 levels at day 5 and LVEF levels at day 180 post-hospitalization [p=0.06]
Conclusion: CCL18 has a correlation with cardiac function in patients with AAMI and it might be considered as an indicator of poor LVEF in patients with AAMI