ABSTRACT
Introduction and Aims: A growing body of evidence indicates the role of inflammation and inflammatory indicators such as Cytokines and other inflammatory mediators as triggering factors in the development of metabolic syndrome [MetS] and other metabolic disorders. This study was designed to investigate the possible association between high sensitivity C reactive proteins [hs-CRP] with components of metabolic syndrome
Materials and Methods: In this case control study a total of 421 individuals including 215 patients with metabolic syndrome and 206 healthy controls were selected randomly from Mashhad as a second largest city in Iran. MetS was defined based on Adult Treatment Panel III criteria. Anthropometric variables such as weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, systolic and diastolic blood pressure as well as biochemical profiles and inflammatory marker [hs-CRP] were measured by standard methods
Results: The mean values of anthropometric and clinical variables, including FBS, TG and total cholesterol, were significantly higher in MetS group compared with controls [P<0.05], while HDL was significantly higher in the control group [P<0.05]. There were no signi?cant differences in the distribution of gender and age between controls and patients with MetS. In subjects with the MetS, hs-CRP concentration was higher than those in controls [P<0.05]. There was also a significant correlation between the concentration of hs-CRP and serum triglyceride levels in men with MetS and serum HDL- cholesterol levels in women of the control group
Conclusion: hs-CRP concentration increased in patients with MetS and was positively associated with TG levels in men and HDLcholesterol in healthy women