ABSTRACT
Background: Health benefits of vitamin D has been proved by a large number of studies, however, to the best of our knowledge there has been no study investigating the effect of mega dose of vitamin D on gestational diabetes mellitus [GDM]. This study was the first to assess the effect of postpartum injection of mega dose of vitamin D on blood pressure [BP] in GDM
Methods: This is a randomized controlled clinical trial conducted on 58 pregnant women suffering from GDM who were randomly assigned into control [CG, n = 24] and intervention group [IG, n = 24]. Patients in intervention group [IG] received an intramuscular injection of 300,000 IU of vitamin D. BP, Serum concentration of 25 [OH] D3, parathyroid hormone [PTH], calcium, phosphor, diastolic [DBP] and systolic blood pressure [SBP] were measured at the baseline and after 3 months
Results: Mega dose supplementation resulted in increased serum 25-hydroxy vitamin D concentrations in IG compared with the CG [62.10 nmol/l compared with 24.10 nmol/l, P < 0.001]. Additionally, injection of vitamin D significantly reduced SBP [98.1 +/- 9.0 mmHg compared with 106.9 +/- 15.9 mmHg, P = 0.02] and slightly decreased DBP but it was not statistically significant [63.3 +/- 1.5 mmHg compared with 73.6 +/- 10.3 mmHg, P = 0.13]. Serum PTH significantly decrease after intervention in IG compared with CG [2.88 +/- 1.60 pmol/l compared with 4.78 +/- 2.4 pmol/l P= 0.003]
Conclusions: This study strongly improved vitamin D status in women with GDM and consequently confirmed the efficacy of a mega dose of vitamin D injection on decreasing of BP
ABSTRACT
During pregnancy and lactation outstanding changes occur in mother's vitamin D metabolism. This study was carried out to evaluate the efficacy of 300,000 IU vitamin D given intramuscularly on body status in new cases of gestational diabetes mellitus [GDM]. This is a randomized clinical trial with the follow-up period of 3 months. Totally 45 participants were randomly divided into intervention group [IG] and control group [CG]. The IG received an IM injection of 300,000 IU of vitamin D, whereas CG did not. The glycosylated hemoglobin A1C [HBA1C], serum 25-OH-D, parathyroid hormone [PTH], serum calcium and phosphorus were measured. Results: Forty five patients including 24 with the mean age of 30.7 +/- 6.2 years in the IG and 21 with the mean age of 29.5 +/- 4.0 years in the CG participated in the study. The median concentration of serum 25[OH]D3 in the IG was to 62.10 nmol/l after the intervention, showing an increase of around 158%, compared to before intervention [24.25 nmol/l] whereas the CG showed a decrease of around 4.5%. Of the patients, 79.2% of IG and 81.9% of CG suffered to some degree from vitamin D deficiency. These figures were 4.2% and 71.4% for the IG and CG, respectively after the intervention.For the IG, the PTH was significantly lower and Ca was significantly higher after the intervention. The serum Phosphorus before and after the intervention in each group or between the two groups was not significant. The single 300,000 IM dose of vitamin D is regarded as an effective and safe to promptly improve vitamin D status in GDM